Biopsy Collection and Repository Database
- Conditions
- Cardiovascular Diseases
- Registration Number
- NCT05521503
- Lead Sponsor
- Andrew Kolodziej
- Brief Summary
Use samples procured from patients to improve understanding of molecular, cellular, and tissue-level processes produced by a variety of cardiac diseases and therapeutic interventions.
- Detailed Description
This is a prospective study enrolling patients referred for or undergoing cardiovascular procedures or treatment at the University of Kentucky. The study aims to facilitate the discovery of novel diagnostic biomarkers and therapeutic targets and improve the pathophysiological understanding of cardiac conditions.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
- All patients undergoing evaluation of a cardiac condition or receiving a right heart catheterization with biopsy clinically indicated who are at least 18 years of age.
- Patients without a cardiovascular or amyloidosis diagnosis, under 18 years of age.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Discover and quantify the concentration of novel diagnostic and prognostic biomarkers 12/21/2021-12/31/2030 Use biospecimens procured from patients with cardiac conditions to identify diagnostic surrogate biomarkers using discovery proteomics. In Cardiac Amyloidosis, the serum levels will be compared between confirmed ATTR and non-ATTR heart failure patients and a diagnostic threshold will be established. The research aims to advance understanding of cardiac diseases and to support the development of improved therapies.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Kentucky
🇺🇸Lexington, Kentucky, United States