Misopristol Versus Pitocin for Second Trimester Abortion

Phase 4

Completed

• Conditions: Abortion, Missed
• Interventions: Drug: mifepristone and misopristol; Drug: mifepristone and oxytocin

• Registration Number: NCT00784797
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

Second trimester abortion can be done surgically or medically. Medical abortion with mifepristone and misopristol is one of the common protocol, but misopristol have high rate side effect. The investigators recent study proved the efficacy of pitocin after mifepristone in second trimester abortion with minimal side effects.

Working hypothesis and aims: To compare misopristol and pitocin after mifepristone preparation in second trimester in seccess rate, interval to abortion, side effects and patient satisfaction.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-11-02
• Study First Submitted QC: 2008-11-03
• Study First Posted: 2008-11-04
• Study Start: 2009-01
• Primary Completion: 2012-06
• Study Completion: 2012-06
• Status Verified: 2013-11
• Last Update Submitted: 2013-11-20
• Last Update Posted: 2013-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 145

Inclusion Criteria

• midtrimester late abortion
• midtrimester induced abortion

Exclusion Criteria

• placenta previa
• infected abortion
• rupture of membranes
• s/p cesarean section *2 or more

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
misopristol	mifepristone and misopristol	vaginal and oral misopristol 48 hours after mifepristone preparation.
pitocin	mifepristone and oxytocin	high dose pitocin drip 48 hours after mifepristone preparation.

Primary Outcome Measures

Name	Time	Method
Success rate of abortion	24 hours
Interval to abortion	24 hours

Secondary Outcome Measures

Name	Time	Method
Side effects	24 hours

Trial Locations

Locations (1)

Hadassah Medical Organization; 🇮🇱 Jerusalem, Israel