Clinical study on the napex acupoint catgut embedding therapy combined with metoprolol tartrate tablet for prophylactic treatment of migraine without aura and brain fMRI mechanism
- Conditions
- migraine
- Registration Number
- ITMCTR2024000185
- Lead Sponsor
- anjing Hospital of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1) Patients who met the diagnostic criteria for migraine without aura and had intermittent episodes at the time of initial treatment in this study;
2) In the range of 18 to 65 years, the course of disease is more than 6 months, the average headache attack is more than 2 times per month;
3) Did not receive preventive treatment of migraine including acupuncture and medicine in the past 1 month;
4) The patient voluntarily received the relevant preventive treatment and signed an informed consent form.
1) Contraindications to the use of metoprolol, including but not limited to patients with symptomatic bradycardia or hypotension, atrioventricular block, morbid sinus syndrome, heart failure, acute myocardial infarction, cardiogenic shock, severe peripheral vascular disease with gangrene, treated with ß agonists, and allergic to any component or other metoprolol of ß blockers;
2) Organic lesions such as tumors, inflammation, and degenerative diseases;
3) Combined with severe neurological, cardiovascular, digestive, urinary, blood system, endocrine system diseases unrelated to migraine;
4) Pregnant and lactating women;
5) Serious mental illness, cognitive impairment so that the normal communication and diagnosis and treatment;
6) Have contraindications to MRI examination such as metal implants in the body and claustrophobia;
7) Have severe asymmetric head anatomical structure or clear lesions found in MRI examination.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the number of headache attack days;frequency of headache attacks;
- Secondary Outcome Measures
Name Time Method headache severity;The Migraine-specific Quality of Life Questionnaire;Amplitude of Low Frequency Fluctuation,ALFF;improved response rate by 50%;