Effect of substitution of intravenous infusion of fentanyl by enteral methadone on the time of weaning from mechanical ventilation in critically ill patients in intensive care units for adults

Not Applicable

Completed

• Conditions: Mechanical ventilation in critically ill adult patients; Respiratory; Mechanical ventilation in critically ill patients

• Registration Number: ISRCTN85308779
• Lead Sponsor: Sao Jose Municipal Hospital (Brazil)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-06-29
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

1. The subjects studied were severely ill patients who required MV and the continuous use of fentanyl and who met the following inclusion criteria:
1.1. MV for at least five days
1.2. The use of fentanyl analgesia in varying doses for at least five day or
1.3. A dose of fentanyl more than or equal to 5 µg/kg/h for at least 12 days.
2. Subjects were also required to meet the following ventilation weaning criteria:
2.1. Reversal of the process that caused the respiratory failure
2.2. Adequate oxygenation (PaO2/FiO2) > 200
2.3. Positive end-expiratory pressure (PEEP) less than or equal to 5; FiO2 less than or equal to 0.4 and pH more than or equal to 7.25
2.4. Hemodynamic stability (with minimal or no vasoactive drugs) and neurological stability (ability to initiate respiratory effort)

Exclusion Criteria

1. Patients younger than 18 years
2. Patients with terminal diseases
2. Patients with cervical spinal cord injuries or neuromuscular diseases

Study & Design

• Study Type: Interventional
• Study Design: Not specified