ISRCTN85308779已完成未知
Replacement of fentanyl infusion by enteral methadone decreases the weaning time from mechanical ventilation: a randomized controlled trial
Sao Jose Municipal Hospital (Brazil)0 个研究点目标入组 75 人开始时间: 2011年6月29日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 75
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. The subjects studied were severely ill patients who required MV and the continuous use of fentanyl and who met the following inclusion criteria:
- •1.1. MV for at least five days
- •1.2. The use of fentanyl analgesia in varying doses for at least five day or
- •1.3. A dose of fentanyl more than or equal to 5 µg/kg/h for at least 12 days.
- •2. Subjects were also required to meet the following ventilation weaning criteria:
- •2.1. Reversal of the process that caused the respiratory failure
- •2.2. Adequate oxygenation (PaO2/FiO2) > 200
- •2.3. Positive end-expiratory pressure (PEEP) less than or equal to 5; FiO2 less than or equal to 0.4 and pH more than or equal to 7.25
- •2.4. Hemodynamic stability (with minimal or no vasoactive drugs) and neurological stability (ability to initiate respiratory effort)
排除标准
- •1. Patients younger than 18 years
- •2. Patients with terminal diseases
- •2. Patients with cervical spinal cord injuries or neuromuscular diseases
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