Effects of ARBs on ambulatory blood pressure, glucose and lipid metabolism, and autonomic nerve function in hypertensive diabetic nephropathy patients
Phase 4
- Conditions
- Hypertension, type 2 diabetes, diabetic nephropathy
- Registration Number
- JPRN-UMIN000000666
- Lead Sponsor
- Department of Cardiorenal Medicine, Yokohama City University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1) Pregnant women, or women suspected of being pregnant 2) Hyperkalemia 3) History of hypersensitivity to Telmisartan or Losartan 4) Severe liver disorder (losartan) 5) Severe biliary atresia or hepatic disorder (telmisartan)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Ambulatory blood pressure monitoring+: mean blood pressure, day-night variation, short-term blood pressure/heart rate variability, LF/HF 2) Renal function: creatinine clearance by Cockcroft-Gault method, urinary protein/albuminon excretion 3) Glucose metabolism: fasting blood glucose, fasting IRI, HOMA-IR. 4) Lipid metabolism: total cholesterol, LDL, HDL, MDA-LDA, oxidised cholesterol, small dense LDL, adiponectin. 5) Vascular function: ABI/baPWV, VEGF, HGF.
- Secondary Outcome Measures
Name Time Method