Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)
- Conditions
- Sturge - Weber Syndrome (SWS)
- Interventions
- Other: blood sample tear drop sample
- Registration Number
- NCT00610402
- Lead Sponsor
- University of California, Irvine
- Brief Summary
Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face. SWS is also accompanied by an increased pressure within the eye (glaucoma) which can develop very early in life.
Glaucoma represents a group of ocular disorders that are characterized by the loss of retinal ganglion cells and their axons, damage to the optic nerve, and gradual loss of visual field. Recently, several studies provided evidence that there is a potential role of the immune system in the pathogenesis of glaucoma.
These findings suggest that there might be changes in systemic humoral immunity possibly underlying the optic neuropathy in at least some glaucoma patients.
- Detailed Description
The ocular antibody profile in patients with SWS is unknown.The researchers want to study on blood and tear drop samples from patients with SWS to determine the incidence of ocular antibodies in patients with this syndrome.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 57
- Male and female volunteers with SWS of all ages
- Volunteers without SWS
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description blood sample tear drop sample blood sample tear drop sample blood sample tear drop sample
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Beckman Laser Institute Medical clinic
🇺🇸Irvine, California, United States