Oral Contraceptive Pill and GnRH Antagonist Versus Long Protocol in IVF Patients

Not Applicable

Completed

• Conditions: Infertility
• Interventions: Drug: levonorgestrel and ethynilestradiol

• Registration Number: NCT01157754
• Lead Sponsor: IVI Madrid

Brief Summary

Recent controversy has arisen regarding the use of the pill for cycle planning in GnRH antagonist IVF cycles. The investigators performed this study to compare such a protocol with the gold-standard still today, which is the long-agonist protocol with no previous use of the pill.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Primary Completion: 2010-05
• Study Completion: 2010-06
• Study First Submitted: 2010-07-06
• Study First Submitted QC: 2010-07-06
• Study First Posted: 2010-07-07
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-21
• Last Update Posted: 2015-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 115

Inclusion Criteria

• 1st or 2nd IVF cycle
• BMI <30 kg/m2
• regular menstrual cycles
• basal FSH <10 IU and E2 <60 pg/ml

Exclusion Criteria

• Polycystic ovaries
• endometriosis
• previous ovarian surgery
• previous low ovarian response

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
long GnRH agonist	levonorgestrel and ethynilestradiol	daily triptorelin starting day 21st of previous cycle
OCP+GnRH antagonist	levonorgestrel and ethynilestradiol	Microgynon 14 to 21 tablets starting COH on day 5 post pill, rFSH + GnRH antagonist

Primary Outcome Measures

Name	Time	Method
implantation rate	2 weeks after the embryo transfer

Trial Locations

Locations (1)

Instituto Valenciano de Infertilidad; 🇪🇸 Madrid, Spain