Oral Estradiol Valerate Versus Oral Contraceptive Pill in Invitro Fertilization Patients

Phase 4

Completed

• Conditions: Infertility
• Interventions: Drug: Levonorgestrel and ethinylestradiol; Drug: Estradiol valerate

• Registration Number: NCT01501448
• Lead Sponsor: IVI Madrid

Brief Summary

The recent controversy regarding the use of pill for cycle planning in GnRH antagonists IVF cycle has driven the search for new ways to plan IVF cycles in order to avoid weekends or to equally distribute the workload. Recently, mid-late luteal phase oral estrogens seem to be as good as the pill. The investigators will compare OCP vs oral estrogens to plan the initiation of IVF cycles.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-12-27
• Study First Submitted QC: 2011-12-28
• Study First Posted: 2011-12-29
• Study Start: 2012-01
• Primary Completion: 2012-05
• Study Completion: 2013-02
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-20
• Last Update Posted: 2016-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 118

Inclusion Criteria

• 1st or 2nd IVF cycle
• BMI <30 kg/m2
• regular menstrual cycles
• basal FSH <10IU and E2 <60pg/mL

Exclusion Criteria

• polycystic ovaries
• endometriosis
• previous ovarian surgery
• previous low ovarian response

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
OCP	Levonorgestrel and ethinylestradiol	-
Oral estradiol valerate	Estradiol valerate	-

Primary Outcome Measures

Name	Time	Method
Implantation rate	20 days after the embryo transfer	number of embryonic sacs visible by ultrasound divided by the number of embryos transferred

Trial Locations

Locations (1)

IVI Madrid; 🇪🇸 Madrid, Spain