NCT00795249已完成早期 1 期
Effects of Chronic Smoking on Circulating Endothelial and Platelet-derived Microparticle
适应症
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- The number of circulating EMP
研究概览
简要总结
The investigators hypothesized that circulating EMP is a useful surrogate marker of early stage of endothelial damage. To determine the effects of chronic smoking on circulating EMP, from healthy volunteers who have habit of chronic smoking, peripheral blood is drawn at the time of flow-mediated dilatation (FMD) examination. Spot urine is also collected. Circulating EMPs are counted using flow-cytometry. After 2-week smoking cessation, the measurements were repeated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy individuals who have no coronary risk factors
排除标准
- •hypertension
- •dyslipidemia
- •chronic kidney disease
- •liver dysfunction
- •obesity (BMI>25.0)
- •cerebrovascular disease
- •other severe systemic diseases (cancer, inflammatory diseases, etc)
结局指标
主要结局
The number of circulating EMP
时间窗: 2 weeks
次要结局
- FMD(2 weeks)
研究者
研究点 (2)
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