Effects of Chronic Smoking on Circulating Endothelial and Platelet-derived Microparticle
Early Phase 1
Completed
- Conditions
- Atherosclerosis
- Interventions
- Behavioral: smoking cessation
- Registration Number
- NCT00795249
- Lead Sponsor
- Kurume University
- Brief Summary
The investigators hypothesized that circulating EMP is a useful surrogate marker of early stage of endothelial damage. To determine the effects of chronic smoking on circulating EMP, from healthy volunteers who have habit of chronic smoking, peripheral blood is drawn at the time of flow-mediated dilatation (FMD) examination. Spot urine is also collected. Circulating EMPs are counted using flow-cytometry. After 2-week smoking cessation, the measurements were repeated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 100
Inclusion Criteria
- healthy individuals who have no coronary risk factors
Exclusion Criteria
- hypertension
- dyslipidemia
- chronic kidney disease
- liver dysfunction
- obesity (BMI>25.0)
- cerebrovascular disease
- other severe systemic diseases (cancer, inflammatory diseases, etc)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description smoker smoking cessation Individuals who have a habit of chronic smoking without any coronary risk factors
- Primary Outcome Measures
Name Time Method The number of circulating EMP 2 weeks
- Secondary Outcome Measures
Name Time Method FMD 2 weeks
Trial Locations
- Locations (1)
Kurume University Hospital
🇯🇵Kurume, Fukuoka, Japan