Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia
- Conditions
- Postoperative Pain
- Interventions
- Registration Number
- NCT03640390
- Lead Sponsor
- Cairo University
- Brief Summary
The aim of this work is to compare the hemodynamic and analgesic properties of Dexmedetomidine and Magnesium sulphate infusion in lower abdominal surgery.
- Detailed Description
Dexmedetomidine is a relatively new alpha 2 adrenergic receptor agonist with a higher α2/α1 selectivity ratio of 1620:1 that provides analgesic and anesthetic effects . Dexmedetomidine has various clinical uses in anesthesia such as sedation, and prolongation of the duration of postoperative analgesia when used as an adjuvant through intrathecal, epidural, or intravenous routes.
Magnesium sulphate is another commonly used drug in anesthesia. Magnesium sulphate suppresses nociceptive impulses through inhibition of voltage-gated calcium channels and through antagonism of the N-methyl D-aspartate (NMDA) receptors.
Although both drugs were reported to prolong the duration of spinal anesthesia, no studies to the best of our knowledge had compared the analgesic and hemodynamic profile of both drugs when used as intravenously during spinal anesthesia.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Adult patients aged between 18 and 65 years.
- Scheduled for lower abdominal surgery.
- Systolic blood pressure less than 100 mmHg
- Coagulation disorders
- History of heart failure
- Mitral or Aortic stenosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Saline group Normal saline This group will receive normal saline infusion Magnesium Sulphate group Magnesium Sulphate This group will receive Magnesium Sulphate infusion at a rate of 15 mg/Kg/hour Dexmedetomidine group Dexmedetomidine This group will receive dexmedetomidine infusion at a rate of 0.5 mcg/kg/hour
- Primary Outcome Measures
Name Time Method Duration of analgesia 24 hours Duration of analgesia after the operation defined as the time till the first analgesic request by the patient
- Secondary Outcome Measures
Name Time Method Systolic blood pressure 6 hours Systolic blood pressure measured in mmHg
Heart rate 6 hours The number of heart beats per minute
Duration of motor block 12 hours The time needed for recovery of motor motor after spinal anesthesia measured in hours
Diastolic blood pressure 6 hours Diastolic blood pressure measured in mmHg
Onset of sensory block 30 minutes after spinal anesthesia The time needed to have complete sensory block after spinal anesthesia measured in minutes
Onset of motor block 30 minutes after spinal anesthesia The time needed to have complete motor block after spinal anesthesia measured in minutes
Ramsay Sedation Scale 12 hours after spinal anesthesia A scale used for assessment of sedation level ranges from 1 (combative) to 6 (unarousable)
Trial Locations
- Locations (1)
Cairo University
🇪🇬Cairo, Egypt