Histopathology Images Based Prediction of Molecular Pathology in Glioma Using Deep Learning or Machine Learning
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Glioma
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
- Enrollment
- 3000
- Locations
- 1
- Primary Endpoint
- AUC of prediction performance
- Status
- Recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
This registry aims to collect clinical, molecular and radiologic data including detailed clinical parameters, molecular pathology (1p/19q co-deletion, MGMT methylation, IDH and TERTp mutations, etc) and images of HE slices in primary gliomas. By leveraging artificial intelligence, this registry will seek to construct and refine histopathology image based algorithms that are able to predict molecular pathology or subgroups of gliomas.
Detailed Description
Non-invasive and precise prediction for molecular biomarkers such as 1p/19q co-deletion, MGMT methylation, IDH and TERTp mutations is challenging. With the development of artificial intelligence, much more potential lies in the histopathology images of HE slices in primary gliomas could be excavated to aid prediction of molecular pathology of gliomas. The creation of a registry for primary glioma with detailed molecular pathology, histopathology image data and with sufficient sample size for deep learning (\>1000) provide considerable opportunities for personalized prediction of molecular pathology with non-invasiveness and precision.
Investigators
Zhenyu Zhang
Principal Investigator
The First Affiliated Hospital of Zhengzhou University
Eligibility Criteria
Inclusion Criteria
- •Patients must have radiologically and histologically confirmed diagnosis of primary glioma
- •Life expectancy of greater than 3 months
- •Must receive tumor resection
- •Signed informed consent
Exclusion Criteria
- •No gliomas
- •No sufficient amount of tumor tissues for detection of molecular pathology
- •Patients who are pregnant or breast feeding
- •Patients who are suffered from severe systematic malfunctions
Outcomes
Primary Outcomes
AUC of prediction performance
Time Frame: up to 10 years
AUC=sensitivity+specificity-1