Acute Effects of Breaks From Sedentary Behavior With Dual Tasks on Cerebral Blood Flow, Cognitive Function, Blood Pressure and Vascular Function in the Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Cerebral blood velocity [centimeters per second]
研究概览
简要总结
The aim of this project will be to compare the acute effects of breaks from sedentary behavior using dual-tasking on cerebral blood flow, vascular function, cognitive functions and blood pressure in elderly people. Participants will perform, in random order, three experimental sessions (control, break with dual-task and standard break ([walk]). All sessions will have a period of 4 hours in sedentary behavior. In the standard break session and in the break session with dual-task participants will take walking and dual-task breaks every 30 minutes, and in the control session they will remain seated without breaks. Before and after this period, cerebral blood flow, vascular function, cognitive functions and blood pressure will be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
盲法说明
The evaluator of flow-mediated dilation is blinded
入排标准
- 年龄范围
- 60 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 60 years or over
- •be physically independent based on the Katz Test
- •have no history of heart attack
- •not having suffered a stroke
- •not have heart failure
- •do not have joint problems that prevent them from carrying out experimental sessions
- •do not have a history of neurodegenerative diseases
- •obtain ≥ 26 points in the Montreal Cognitive Assessment (MoCA)
- •are not involved in the practice of regular, systematic physical activity more than once a week over the last six months prior to the start of the study
- •not be smokers and morbidly obese.
排除标准
- 未提供
研究组 & 干预措施
Break dual task
Subjects will remain seated for three hours; however, every 30 minutes the subjects will be instructed to stand and take short walks with low intensity and perform a cognitive task
干预措施: Break of sedentary behavior with dual task (Other)
Standard break
Subjects will remain seated for three hours, however, every 30 minutes the subjects will be instructed to stand and take short walks at low intensity for two minutes,
干预措施: Break of sedentary behavior with walking (Other)
Control session
Subjects will remain seated for three hours
结局指标
主要结局
Cerebral blood velocity [centimeters per second]
时间窗: Before and 20 minutes after the intervention for 5 minutes
Mean arterial velocity of middle cerebral artery will be measured using a transcranial doppler
Cognitive function - verbal fluency [number of animal names reported]
时间窗: Before and 35 minutes after the intervention
The task will consist of recalling words that begin with the letter "F", for 60 seconds. The final score will be determined according to the number of correct words reported in 60 seconds. In the semantic modality, participants must evoke as many animals as possible in 60 seconds. The final score will be determined according to the number of animal names reported in 60 seconds.
Cognitive function - The Trail Making Tests [seconds]
时间窗: Before and 30 minutes after the intervention
The Trail Making Tests (A and B) will be used to assess executive function and attention. Part A will determine psychomotor speed and require the participant to draw lines connecting sequentially circled numbers, such as drawing a line from 1 to 2, 2 to 3, and 3 to 4. Part B will consist of circled numbers and letters. Participants will be instructed to draw a line as quickly and as accurately as possible from 1 to A, A to 2, 2 to B, B to 3, and so on, until they complete the task. The time in seconds will be recorded in seconds after the end of each stage. After carrying out the tests, the differences between the completion times for part B - A will be calculated.
Cognitive function - Stroop test [seconds]
时间窗: Before and 32 minutes after the intervention
A computerized version of the Stroop test will be used in this study, using the Testinpacs® program. The tasks will be viewed on a notebook screen approximately 90 cm away from the participant. Answers to a set of tasks will be given as quickly as possible via two buttons. The cognitive portion of the Stroop test will be used as a psychometric test to assess cognition, being related to the executive functions of decision-making and inhibitory control exercised by the prefrontal cortex. The capacity for selective attention and response control will be estimated as the time difference between the third condition and the second condition. Smaller differences will indicate better selective attention and conflict resolution.
次要结局
- Resting systolic and diastolic blood pressures [mmHg](Before and 10 minutes after the intervention)
- Resting heart rate [bpm](Before and 10 minutes after the intervention)
- Ambulatory systolic, diastolic, and mean blood pressures monitoring [mmHg](45 minutes after the intervention)
- Vascular function [%](Before and 10 minutes after the intervention)
研究者
Raphael Mendes Ritti Dias
Principal Investigator
University of Nove de Julho