Research on the dynamic changes of amino acids in the body after intaking amino acid containing foods

Not Applicable

• Conditions: Healthy volunteers

• Registration Number: JPRN-UMIN000038264
• Lead Sponsor: SOUSEIKAI Sumida Hospital

Brief Summary

We confirmed the time course of blood amino acid concentration when ingesting amino acid-containing foods before and between meals, and obtained the kinetic data of amino acids for considering the intake dose and the effect of meals.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-10-21
• Study Completion: 2019-11-24
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Not provided

Exclusion Criteria

Who has been commented on any cognitive declines or diagnosed with dementia from physicians. Who is under treatment for any life style related disease such as Diabetes Mellitus, Hyperlipidemia, or Hypertension. Who is under medication. Who has cancer (diagnosis and under treatment), or is within 5 years after the completion of cancer treatment. Who has current diseases such as Cirrhosis, Renal failure, congenital metabolic disease of amino acids or who is on Hemodialysis. Who has a history of surgery on any digestive organs or liver, gall bladder, pancreas. (Appendectomy is acceptable) Who has Alcohol dependency, nicotine dependency. Who has any food allergies or is lactose intolerant. Who has anemia, malnutrition, or viral diseases or any serious diseases or symptoms. Who has been taking any amino acids or protein enhancement food/supplements within 1 month from the first consumption of the study food. Who has taken more than 200 mL of blood within 1 month. Who is currently participating in any other studies that involves using any foods, cosmetics or medications. Who has been confirmed any abnormal clinical values of the level of [Medical Consultation needed] at a screening test. Who has been considered ineligible by the study doctor.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To analyze the changes of amino acid concentrations in the blood. (Amino acids to be analyzed; those included in the test food, those not included in the test food, the metabolites.) To simulate the inflow speed of amino acids and the metabolites using the uptake kinetics of amino acid transporters that are being expressed on human BBB based on the changes of blood amino acid concentrations.