Salivary Interleukin-32, Interleukin-10, Interleukin-6 and Tumor Necrosis Factor-alpha Levels in Children

Completed

• Conditions: Early Childhood Caries
• Interventions: Diagnostic Test: ELISA

• Registration Number: NCT04958005
• Lead Sponsor: Aydin Adnan Menderes University

Brief Summary

This study aimed to evaluate the levels of interleukin 10, interleukin 6, interleukin 32 and tumor necrosis factor-alpha (TNF-α) in saliva of children with early childhood caries.

Detailed Description

Fifty six children ( 28 with early childhood caries and 28 without early childhood caries ; age range 3-6 years) will be recruited for the study. Probing pocket depth (PPD), gingival index (GI) and plaque index (PI) will be recorded and saliva samples will be collected. Interleukin-32, Interleukin-10, Interleukin-6 and TNF-α will be analyzed in saliva samples by ELISA.

Study Timeline

• Study Start: 2021-07-01
• Study First Submitted: 2021-07-01
• Study First Submitted QC: 2021-07-01
• Study First Posted: 2021-07-12
• Primary Completion: 2021-08-30
• Study Completion: 2021-09-30
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-20
• Last Update Posted: 2021-10-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• Children with untreated early chilhood caries
• Age between 3 and 6 years

Exclusion Criteria

• Having a systemic problem or mental retardation
• Children with treated caries

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Children with early chilhood caries	ELISA	Early chilhood caries group
Without early chilhood caries	ELISA	Control group

Primary Outcome Measures

Name	Time	Method
IL-32	Baseline	Interleukin- 32 level
IL-10	Baseline	Interleukin- 10 level

Secondary Outcome Measures

Name	Time	Method
Tnf-Alpha	Baseline	Tnf-alpha level
IL-6	Baseline	Interleukin- 6 level

Trial Locations

Locations (1)

Sultan KELEŞ; 🇹🇷 Aydın, Turkey