Effects of White Rice, Brown Rice, and Black Rice on Postprandial Glucose and Lipid Profiles in Healthy Korean Adults

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: White rice diet; Dietary Supplement: Brown rice diet; Dietary Supplement: Black rice diet; Dietary Supplement: Bread; Other: Glucose solution

• Registration Number: NCT01932086
• Lead Sponsor: Chonbuk National University Hospital

Brief Summary

This study was an open, 5-treatment, 5-sequence, 5-day cross-over randomized design clinical trial. The present study was carried out to compare the effects of white rice, brown rice, and black rice on postprandial glucose and lipid profiles in healthy human subjects, using a white bread as a positive control.

Detailed Description

After a 12-hour fast, oral glucose and meal tolerance was measured with blood samples drawn at times 0, 15, 30, 45, 60, 90, 120, 150 and 180 minutes and TG was at time 0, 1, 2, 3, 4, 5 and 6 hours.

1. Serum levels of glucose, insulin, and TG were analyzed by biochemical autoanalyzer. The area under the curve (AUC) changes in blood glucose, TG were computed by the trapezoidal method.

2. Glycemic index(GI): the area under the glucose response curve after consumption of a test food divided by the area under the curve after consumption of a control food containing the same amount of carbohydrate and calculated using 50 g glucose as the reference.

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2011-04
• Study Completion: 2011-10
• Status Verified: 2013-08
• Study First Submitted: 2013-08-21
• Study First Submitted QC: 2013-08-27
• Study First Posted: 2013-08-30
• Last Update Submitted: 2013-08-30
• Last Update Posted: 2013-09-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• Males, 19~60years old
• Bodyweight was more than 50 kg with ideal body weight within ±30%
• triglyceride (TG) levels less than 200 mg/dL
• Fasting blood glucose levels less than 100 mg/dL and an oral glucose tolerance test (OGTT) less than 140 mg/dL
• Able to give informed consent

Exclusion Criteria

• Major medical illness such as cardiovascular, neurologic, psychiatric, renal, pulmonary and hepatic diseases
• History of disease that could interfere with the test products or impede their absorption such as gastrointestinal disease or gastrointestinal surgery
• Medical or psychological conditions deemed by the investigators to interfere with successful participation in the study
• Poor vital sign (systolic blood pressure: below 100 mmHg or above 150 mmHg, diastolic blood pressure: below 65 mmHg or above95 mmHg)
• Allergic or hypersensitive to any of the ingredients in the test products; treated with any drug within past 2 weeks
• Participation in any other clinical trials within past 2 months
• Alcohol consumption above 21 units per week or abnormal screening laboratory test
• Being judged by the responsible physician of the local study center as unfit to participate in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
White rice	White rice diet	-
White rice	Brown rice diet	-
White rice	Black rice diet	-
White rice	Bread	-
White rice	Glucose solution	-
Brown rice	White rice diet	-
Brown rice	Brown rice diet	-
Brown rice	Black rice diet	-
Brown rice	Bread	-
Brown rice	Glucose solution	-
Black rice	White rice diet	-
Black rice	Brown rice diet	-
Black rice	Black rice diet	-
Black rice	Bread	-
Black rice	Glucose solution	-
Bread	White rice diet	-
Bread	Brown rice diet	-
Bread	Black rice diet	-
Bread	Bread	-
Bread	Glucose solution	-
Glucose solution	White rice diet	-
Glucose solution	Brown rice diet	-
Glucose solution	Black rice diet	-
Glucose solution	Bread	-

Primary Outcome Measures

Name	Time	Method
1. Glucose, insulin AUC(incremental area under the curve) 2. Glycemic index(GI)	2 hour postprandial blood glucose, insulin	1. Plasma glucose and insulin will be measured at baseline, 15, 30, 45, 60, 90, 120, 180 and 240 minutes post ingestion of each test solution, and area under the curve will be calculated.; 2. Glycemic index (GI) was defined as the area under the glucose response curve after consumption of a test food divided by the area under the curve after consumption of a control food containing the same amount of carbohydrate and calculated using 50 g glucose as the reference. Plasma glucose will be measured at baseline, 15, 30, 45, 60, 90, and 120 minutes post ingestion of each test solution.; GI= (incremental blood glucose area of test meal/incremental area of glucose) × 100

Secondary Outcome Measures

Name	Time	Method
Triglyceride iAUC(incremental area under the curve)	6 hour postprandial blood triglyceride(TG)	Triglyceride will be measured at baseline, 0, 1, 2, 3, 4, 5 and 6 hours post ingestion of each test solution, and area under the curve will be calculated.

Trial Locations

Locations (1)

Clinical Trial Center for Functional Foods; Chonbuk National University Hospital; 🇰🇷 Jeonju, Jeollabuk-do, Korea, Republic of