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临床试验/NCT07121686
NCT07121686尚未招募不适用

Effect of Red and Blue Light Irradiation on Wound Healing After Hemorrhoid Surgery: A Single - Center Prospective Open - Label Randomized Clinical Trial

The Affiliated Hospital of Putian University1 个研究点 分布在 1 个国家目标入组 315 人开始时间: 2025年8月15日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
315
试验地点
1
主要终点
Wound healing time

研究概览

简要总结

The subjects of this study were patients who took mixed haemorrhoidectomy during the period of December 2024 - December 2025 . The haemorrhoidectomy patients were randomly divided into routine group, red light group and red and blue light group, and were given different ways of trauma care, and the number of cases in each group was 105 , with a total of 305 cases. Observe the difference between red and blue light irradiation and routine care on the healing time of postoperative trauma and postoperative complications after haemorrhoidectomy, and evaluate the patients' quality of life and satisfaction with treatment under both red light irradiation and routine care.

详细描述

The subjects of this study were patients who took mixed haemorrhoidectomy during the period of December 2024 - December 2025 . The diagnostic criteria were haemorrhoidal disease diagnosed as degree III-IV according to Goligher's classification. Inclusion criteria were 18 years < age < 75 years; diagnosis of haemorrhoids; internal haemorrhoid ligation + external haemorrhoidectomy. Exclusion criteria were patients with psychiatric disorders; patients with chronic diseases such as diabetes mellitus, hypertension and coronary artery disease; patients who underwent other treatments in addition to haemorrhoidectomy such as haemorrhoidal radiofrequency ablation/ sclerotherapy; patients who were unable to cooperate with the follow-up; and patients with perianal abscess, anal fissure, anal fistulae, and anorectal papillae hypertrophy. The haemorrhoidectomy patients were randomly divided into the conventional group, the red light group and the red and blue light group, and were given different ways of trauma care, and the number of cases in each group was 105 , with a total of 305 cases. The control group was given routine potassium permanganate sitz bath and routine care after internal haemorrhoid ligation + external haemorrhoidectomy to encourage patients to carry out functional exercise in moderation, mainly for anal lifting, buttock lifting and abdominal massage, etc.; the red light group was based on the control group, using red light irradiation for traumatic treatment; the red and blue light group was based on the control group, using red and blue light irradiation for traumatic treatment. Observe the difference between red and blue light irradiation and routine care on the healing time of postoperative trauma and postoperative complications after haemorrhoid surgery, and evaluate the patients' quality of life and satisfaction with treatment under both red light irradiation and routine care. Specific research content is to collect the postoperative data of the three groups of patients, including the recording of surgery-related pain scores, respectively, before the red light intervention and after the intervention of 1 d, 2 d, 3 d, 5 d, 7 d using visual analogue scoring (VAS) to assess the intensity of the patient's pain; the recording of the length of hospital stay; the recording of the degree of oedema of the anal verge were assessed before the red light intervention and after the intervention of 1 d, 2 d, 3 d, 5 d, 7 d, respectively, 0 Score 0: no oedema or slight oedema on the wound, but no impact on life. Score 2: oedema is present in only one area of the wound and is less than 1 cm in diameter, affecting daily activities. 4 points: multiple oedemas with a diameter of 1-2 cm, affecting daily activities. 6 points: multiple oedemas with a diameter of more than 2 cm, seriously affecting daily activities; follow up on the time to complete healing of the wound, quality of life scores, and the patient's satisfaction with the treatment.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Aged 18-75 years
  • Diagnosed with Grade III-IV hemorrhoids according to Goligher classification
  • Scheduled to undergo rubber band ligation of internal hemorrhoids + external hemorrhoidectomy
  • Willing and able to provide written informed consent
  • Able to comply with postoperative follow-up and treatment protocol

排除标准

  • Psychiatric disorders or cognitive impairment
  • Uncontrolled chronic diseases:
  • Diabetes (HbA1c >7.5%)
  • Hypertension (BP >160/100 mmHg)
  • Coronary artery disease (NYHA Class III-IV heart failure)
  • Concurrent other hemorrhoid treatments (e.g., radiofrequency ablation/sclerotherapy)
  • Inability to complete follow-up (e.g., living too far away, no stable contact)
  • Concurrent anal disorders:
  • Perianal abscess
  • Anal fissure
  • Anal fistula
  • Hypertrophied anal papilla
  • Pregnancy or lactation (for female patients)
  • History of phototherapy allergy
  • Participation in other clinical trials within 3 months
  • For registration, simply copy this structured list directly into the PRS system's eligibility section. The clear formatting will facilitate efficient review.

结局指标

主要结局

Wound healing time

时间窗: Daily from Day 1 until complete epithelialization (max 28 days post-op)

Defined as 100% re-epithelialization assessed by blinded evaluator

次要结局

  • Postoperative pain intensity (VAS score)(Baseline, Day 1, 2, 3, 5, 7, and Day 14±2)
  • Perianal edema severity (0-6 scale)(Day 1, 2, 3, 5, 7, and Day 14±2)
  • Length of hospital stay(From surgery end to discharge (up to 7 days))
  • Complication incidence(Within 30 days postoperatively)

研究者

发起方
The Affiliated Hospital of Putian University
申办方类型
Other
责任方
Sponsor

研究点 (1)

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