Skeletal muscle atrophy in elderly hip surgery patients during hospital admission.
- Conditions
- Hip fracture, elective hip surgery, muscle loss, falls and fractures
- Registration Number
- NL-OMON23029
- Lead Sponsor
- Maastricht University Medical CentreTIFN: Top Institute for Food and Nutrition
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1. Hip fracture or osteoarthritis of the hip;
2. >65 years of age;
Exclusion Criteria
1. Co-morbidities and neuromuscular disorders of the lower limbs severely interacting with mobility;
2. Co-morbidities severely interacting with muscle metabolism of the lower limbs;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary parameters in this study are the cross-sectional area of the quadriceps muscle and the cross-sectional area of type I and type II skeletal muscle fibers.
- Secondary Outcome Measures
Name Time Method Secondary outcome parameters in this study are satellite cell content in the type I en type II skeletal muscle fibers, functional outcome 6 months after hospital admission (determined by the use of the PASE score and Hip Fracture Functional Recovery Scale), and quality of life (SF-36) 6 months after admission.<br /><br>Baseline subject characteristics will be obtained, including height, bodyweight, medical history, use of medication, mental status (determined by the MMSE), smoking, use of alcohol, use of drugs, level of habitual physical activity (determined by PASE, Hip Fracture Recovery Scale), and quality of life (SF-36). The nutritional status of the patients will also be measured, using the MNA and MUST questionnaires. Lean body mass and bone mineral density will be determined by DEXA. In addition, blood samples will be analyzed for HbA1c, CRP, calcidiol, and TNF-á.