Skeletal muscle atrophy in elderly hip surgery patients during hospital admissio

Recruiting

Conditions: muscle atrophy
muscle wasting
Sarcopenia
10028302

Registration Number: NL-OMON39745

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

Hip fracture or osteoarthritis of the hip, >65 years of age, operative treatment
Healthy elderly subjects, mentally competent, age-matched with fracture patients

Exclusion Criteria

- Co-morbidities and neuromuscular disorders of the lower limbs severely interacting with mobility
- Co-morbidities severely interacting with muscle metabolism of the lower limbs
- Known renal malfunction (Known renal malfunction without documented approval from nephrologist)
- Known allergy to milk, milk products and soy
- Known galactosaemia
- A life-expectancy of less than 6 months

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary parameters in this study are the cross-sectional area of the<br /><br>quadriceps muscle and the cross-sectional area of type I and type II skeletal<br /><br>muscle fibers.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome parameters in this study are satellite cell content in the<br /><br>type I en type II skeletal muscle fibers, functional outcome 6 months after<br /><br>hospital admission (determined by the use of the PASE score and Hip Fracture<br /><br>Functional Recovery Scale), and quality of life (SF-36) 6 months after<br /><br>admission.<br /><br>Baseline subject characteristics will be obtained, including height,<br /><br>bodyweight, medical history, use of medication, mental status (determined by<br /><br>the MMSE), smoking, use of alcohol, use of drugs, level of habitual physical<br /><br>activity (determined by PASE, Hip Fracture Recovery Scale), and quality of life<br /><br>(SF-36). The nutritional status of the patients will also be measured, using<br /><br>the MNA and MUST questionnaires. Lean body mass and bone mineral density will<br /><br>be determined by DEXA. In addition, blood samples will be analyzed for HbA1c,<br /><br>CRP, calcidiol, and TNF-a. </p><br>