Relationships Between Exercise and Appetite in Women With Loss of Control Eating
Not Applicable
Recruiting
- Conditions
- Eating DisordersBinge-Eating DisorderBulimia Nervosa
- Interventions
- Behavioral: RestBehavioral: Fed ExerciseBehavioral: Fasted Exercise
- Registration Number
- NCT06602973
- Lead Sponsor
- Ohio University
- Brief Summary
This pilot study is a first step in looking at the relationship between exercise and appetite in women with loss of control eating.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 26
Inclusion Criteria
- Engage in loss of control eating at least 12 times in the last three months
- Clinically significant eating disorder-related impairment (CIA > 15)
- Taking hormonal contraception
- Minimum VO2max of 50th percentile for age and sex assigned at birth
- Be willing to eat study-provided foods
- Likes chocolate (at least 6/10 on 10 point scale)
Exclusion Criteria
- BMI < 18.5 kgm/2
- Medical conditions that affect appetite or weight (e.g., diabetes mellitus, thyroid disease)
- Recent pregnancy or breastfeeding (prior 6 months)
- Relevant food allergies (e.g., wheat, chocolate)
- Specific phobia, blood-injection-injury type
- Medical condition that precludes safe participation in exercise (e.g., stress fracture)
- Medications that acutely affect appetite (e.g., GLP-1 agonists; psychiatric medications allowed)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Rest, Fed Exercise, Fasted Exercise Rest At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will abstain from breakfast and will engage in exercise. Rest, Fed Exercise, Fasted Exercise Fed Exercise At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will abstain from breakfast and will engage in exercise. Fed Exercise, Rest, Fasted Exercise Fed Exercise At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will abstain from breakfast and will engage in exercise. Fed Exercise, Rest, Fasted Exercise Fasted Exercise At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will abstain from breakfast and will engage in exercise. Fed Exercise, Fasted Exercise, Rest Rest At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise). Rest, Fed Exercise, Fasted Exercise Fasted Exercise At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will abstain from breakfast and will engage in exercise. Rest, Fasted Exercise, Fed Exercise Rest At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and exercise. Rest, Fasted Exercise, Fed Exercise Fed Exercise At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and exercise. Rest, Fasted Exercise, Fed Exercise Fasted Exercise At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and exercise. Fed Exercise, Rest, Fasted Exercise Rest At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will abstain from breakfast and will engage in exercise. Fed Exercise, Fasted Exercise, Rest Fed Exercise At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise). Fed Exercise, Fasted Exercise, Rest Fasted Exercise At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise). Fasted Exercise, Fed Exercise, Rest Rest At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise) Fasted Exercise, Fed Exercise, Rest Fed Exercise At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise) Fasted Exercise, Fed Exercise, Rest Fasted Exercise At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise) Fasted Exercise, Rest, Fed Exercise Rest At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will eat breakfast and exercise. Fasted Exercise, Rest, Fed Exercise Fed Exercise At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will eat breakfast and exercise. Fasted Exercise, Rest, Fed Exercise Fasted Exercise At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will eat breakfast and exercise.
- Primary Outcome Measures
Name Time Method Relative Energy Intake Food intake from 8 am to 8 am; Energy expenditure from approximately 9 am to 9:05 am and 9:25 to 9:30 am, coinciding with study condition (rest or exercise) Relative energy intake for 24 hours will be calculated as absolute energy intake from the breakfast (if consumed), lunch, food reward value task, and take home cooler minus energy expenditure during exercise (or comparable time period during rest).
- Secondary Outcome Measures
Name Time Method Self-reported binge eating 24 and 48 hours after exercise/rest study visit Participants will rate the extent the following questions, considering the time frame "since yesterday morning at 8 am" on a 1 to 5 scale from "not at all" to "extremely":
"While you were eating, to what extent did you feel a sense of loss of control?," "While you were eating, to what extent did you feel that you could not resist eating," "While you were eating, to what extent did you feel that you could not stop eating once you had started," and "While you were eating, to what extent did you feel driven or compelled to eat?" An answer of 4 or higher on any item will be categorized as binge eating present. Any reported binge eating on either day will be coded as binge eating being presentFood reward value Approximately 3:30 pm day of study visit Number of trials according to task developed by Bodell and Keel 2015
Lactate 30 minutes, pre-post exercise (or rest) Lactate values
Acylated ghrelin Immediately prior to lunch Acylated ghrelin
Trial Locations
- Locations (1)
Ohio University
🇺🇸Athens, Ohio, United States