Relationships Between Exercise and Appetite in Women With Loss of Control Eating

Not Applicable

Recruiting

• Conditions: Eating Disorders; Binge-Eating Disorder; Bulimia Nervosa

• Registration Number: NCT06602973
• Lead Sponsor: Ohio University

Brief Summary

This pilot study is a first step in looking at the relationship between exercise and appetite in women with loss of control eating.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-08-30
• Study First Submitted: 2024-09-12
• Study First Submitted QC: 2024-09-17
• Study First Posted: 2024-09-19
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-12
• Last Update Posted: 2025-05-15
• Primary Completion: 2026-08
• Study Completion: 2026-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 26

Inclusion Criteria

• Engage in loss of control eating at least 12 times in the last three months
• Clinically significant eating disorder-related impairment (CIA > 15)
• Taking hormonal contraception
• Minimum VO2max of 50th percentile for age and sex assigned at birth
• Be willing to eat study-provided foods
• Likes chocolate (at least 6/10 on 10 point scale)

Exclusion Criteria

• BMI < 18.5 kgm/2
• Medical conditions that affect appetite or weight (e.g., diabetes mellitus, thyroid disease)
• Recent pregnancy or breastfeeding (prior 6 months)
• Relevant food allergies (e.g., wheat, chocolate)
• Specific phobia, blood-injection-injury type
• Medical condition that precludes safe participation in exercise (e.g., stress fracture)
• Medications that acutely affect appetite (e.g., GLP-1 agonists; psychiatric medications allowed)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Relative Energy Intake	Food intake from 8 am to 8 am; Energy expenditure from approximately 9 am to 9:05 am and 9:25 to 9:30 am, coinciding with study condition (rest or exercise)	Relative energy intake for 24 hours will be calculated as absolute energy intake from the breakfast (if consumed), lunch, food reward value task, and take home cooler minus energy expenditure during exercise (or comparable time period during rest).

Secondary Outcome Measures

Name	Time	Method
Self-reported binge eating	24 and 48 hours after exercise/rest study visit	Participants will rate the extent the following questions, considering the time frame "since yesterday morning at 8 am" on a 1 to 5 scale from "not at all" to "extremely": "While you were eating, to what extent did you feel a sense of loss of control?," "While you were eating, to what extent did you feel that you could not resist eating," "While you were eating, to what extent did you feel that you could not stop eating once you had started," and "While you were eating, to what extent did you feel driven or compelled to eat?" An answer of 4 or higher on any item will be categorized as binge eating present. Any reported binge eating on either day will be coded as binge eating being present
Food reward value	Approximately 3:30 pm day of study visit	Number of trials according to task developed by Bodell and Keel 2015
Lactate	30 minutes, pre-post exercise (or rest)	Lactate values
Acylated ghrelin	Immediately prior to lunch	Acylated ghrelin

Trial Locations

Locations (1)

Ohio University; 🇺🇸 Athens, Ohio, United States