Bio-clinical Evolutive Dynamic in Patients Suffering From Communitary Septic Shock (Biosepsis)
Completed
- Conditions
- Immunocompetent Patient on Septic Shock
- Registration Number
- NCT01668329
- Lead Sponsor
- University Hospital, Grenoble
- Brief Summary
Septic shock is a frequent pathology responsible for over 30000 deaths/year in France. Its outcome has not been improved despite the knowledge on inflammatory processes; a reason for these lack of results may lay on the lack of data on the precise dynamics of inflammatory and anti-inflammatory cascades and their consequences. We intend to achieve accurate monitoring of the inflammatory process on a small group of non-immunocompromised patients. Our goal is to obtain quality data, repeated over time, by limiting the technical variability.
- Detailed Description
The aim is to obtain precise data on the dynamics of cytokines, oxydative stress and hormonal response on immunocompetent adults during septic shock.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
- Patient over 18 years admitted in ICU.
- Clinical evidence of infection, suspected or proved, during the 48hrs following the hospital entry.
- Systemic inflammatory response syndrome.
- Shock defined as arterial hypotension (<90mmHg)not responding to adequated filling.
Exclusion Criteria
- Minors
- Patient under guardianship or trusteeship
- Pregnant or lactating women
- Not affiliated to the social security
- Deprived of liberty by court decision
- Patients hospitalised without their approval
- Shock related to another cause than infection
- Long term corticothérapy
- On-going chemiothérapy, AIDS
- Bedridden patient
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evolutive profile of the inflammatory response during septic shock Hospitalisation in ICU
- Secondary Outcome Measures
Name Time Method Research for early prognosis factors Hospitalisation in ICU
Trial Locations
- Locations (1)
University Hospital Grenoble
🇫🇷Grenoble, France