Effects of a high-fat and a low-fat diet on early biomarkers of metabolic stress in blood and gene expression in the small intestine of healthy subjects - Effects of high-fat and low-fat diet on the gut

niversiteit Maastricht0 个研究点目标入组 10 人开始时间: 待定最近更新: 2024年5月13日

适应症

试验速览

暂无简介。

•- BMI <= 18 and >= 30 kg/m2
•- Serum Total cholesterol > 8.0 mmol/L
•- Fasting glucose > 7.0 mmol/L
•- Use of any medication
•- Active cardiovascular diseases like congestive heart failure or recent (<6 months) event (acute myocardial infarction, CVA)
•- Gastrointestinal diseases (like celiac disease, inflammatory bowel disease, irritable bowel disease and food allergies) or a history of any gastrointestinal disorders or complaints
•- Pre-existing gallbladder disease
•- Diabetes mellitus
•- Familial hypercholesterolemia
•- Severe medical conditions that might interfere with the study such as epilepsy, asthma, COPD and rheumatoid arthritis.
•- Unstable body weight (weight gain or loss > 3 kg in the past three months)
•- Impairment of renal function, as evidenced by increased serum creatinine >150 mmol/L
•- Hepatic diseases as manifested by ALT, AST, GGT, total bilirubin or ALP > 2 times the upper limit of normal
•- CRP values > 8.0 mg/mL
•- Abuse of drugs and/or alcohol
•- Participation in another biomedical study within 1 month prior to the start of this study
•- Having donated blood (as blood donor) within 1 month prior to start of this study

发起方