Comparing effect of drug Melatonin in reducing stress response to anesthesia interventions during bypass heart surgery in smokers and non smokers
Not Applicable
- Conditions
- Health Condition 1: I259- Chronic ischemic heart disease, unspecified
- Registration Number
- CTRI/2021/09/036367
- Lead Sponsor
- A J INSTITUTE OF MEDICAL SCIENCES
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All patients scheduled for elective CABG surgery belonging to patientâ??s physical status American Society of Anesthesiologists (ASA) classes 1,2,3&4 with history of cigarette smoking- 10 or more cigarettes per day for more than one year and non-smoker patients.
Exclusion Criteria
1.Patients with history of OSA
2.Patients with hypovolemia
3.Patients with history of bronchial asthma
4.Patients with history of laryngeal or tracheal surgery
5.Patients with persistent pre-induction BP->=160/90 mm of hg
6.Patients with anticipated difficult airway
7.Patients with ASA class 5 or more
8.Duration of Laryngoscopy >1 Minute
9.More than 1 attempt of intubation
10.Laryngoscopic grade >2B
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome- <br/ ><br> To find out the hypnotic efficacy of oral Melatonin on hemodynamic changes during tracheal intubation in smokers and non-smokers undergoing elective off-pump CABG surgery. <br/ ><br>Timepoint: <br/ ><br>Maximum rise of HR and MAP were noted during tracheal intubation. Heart rate, SAP, DAP, and MAP were recorded after stabilization of patient for 3 minutes before induction, during intubation, and at 1,2, 3, 5, and 10 min after intubation.
- Secondary Outcome Measures
Name Time Method Secondary outcome- <br/ ><br>1.Comparison of hemodynamic changes during tracheal intubation in smokers and non-smokers. <br/ ><br>2.Hemodynamic changes during tracheal intubation. <br/ ><br>3.Side effects of the drug administered.Timepoint: Maximum rise of HR and MAP were noted during tracheal intubation. Heart rate, SAP, DAP, and MAP were recorded after stabilization of patient for 3 minutes before induction, during intubation, and at 1,2, 3, 5, and 10 min after intubation