Comparison of addition of a sedative drug Dexmedetomidine in Local Anaesthetic drug Ropivacaine 0.1% concentration mixture with plain Ropivacaine in regional Nerve block given for pain relief after Knee Replacement surgery

Not yet recruiting

Conditions: Osteoarthritis of knee, unspecified, (2) ICD-10 Condition: M171||Unilateral primary osteoarthritisof knee,

Registration Number: CTRI/2023/02/049732

Lead Sponsor: SIR H N RELIANCE FOUNDATION HOSPITAL AND RESEARCH CENTRE

Brief Summary: The main aim of this study is to investigate the duration of analgesia of ACB using ropivacaine with and without dexmedetomidine after unilateral TKR in first 24 hrs, both at rest and moving and to record pain score and opioid consumption among 2 groups.The study population will be composed of patients of either gender,aged above 18 years and below 80 years and posted for unilateral total knee replacement under spinal anesthesia at a tertiary health care centre.Data will be collected between Jan 2023 to july 2024.Analysis of the parameters will be done after complete data collection.At any point of time,the patients enrolled can be dropped out of the study.

Sample size is calculated as 64 in number,which will be div ided into 2 groups, control group(C) and Dexmedetomidine group (D).Control group consisting of 0.1% Ropivacaine 20mL and Dexmedetomidine group with 0.1% Ropivacaine + 0.5mcg/kg Demedetomoidine through adductor canal block and Pain assessment done postoperatively evry 6th hourly for 24 hours and results assessed including the Pain score, side effects of adjuvant dexmedetomidine and opiod consumption.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 64

Inclusion Criteria

ASA grade 1,2,3 scheduled for unilateral total knee replacement under spinal anesthesia BMI 20-30kg/m2.

Exclusion Criteria

allergic to any study drugs pregnant patients patients in whom nerve block could not be performed as per methodology patients on pre operative oral opioids patients and or relatives not willing for procedure ASA grade 4 ,age <18 and >80yrs BMI >30kg/m2 patients on chronic pain medication any severe perioperative complications.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate duration of analgesia of ACB using ropivacaine with and without dexmedetomidine after unilateral TKR in first 24 hrs ,both at rest and moving	6hr,12hr,18hr,24hr

Secondary Outcome Measures

Name	Time	Method
to evaluate opioid consumption in first 24 hours of surgery	6hr,12hr,18hr,24hr

Trial Locations

Locations (1): Sir H N Reliance Foundation Hospital
🇮🇳
Mumbai, MAHARASHTRA, India
Sir H N Reliance Foundation Hospital
🇮🇳Mumbai, MAHARASHTRA, India
SULFATH P
Principal investigator
7306129766
pzulphath@gmail.com