Treatment of Polytraumatisms With Corticoids
- Registration Number
- NCT00563303
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
Interest of treatment of polytraumatisms with corticoids (hydrocortisone) for patient with relative adrenocortical insufficiency on frequency of nosocomial infection, and hemodynamic complications and organs injuries.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- Age superior of 15 years
- Hospitalization in reanimation for polytraumatism (lesion of two organs with a vital risk)
- SISS score more than 15
- Intubation for more than 48 hours.
- Agreement of a family member
- Patient with insurance
Exclusion Criteria
- History of corticothérapies within 6 months
- History of adrenocortical insufficiency.
- Treatment by immunosuppressor
- Immunodeficiency.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description H hydrocortisone Hydrocortisone P NaCl Treatment by NaCl (placebo)
- Primary Outcome Measures
Name Time Method Incidence of nosocomial pneumopathy: radiological, clinical and bacteriological criteria 28 days
- Secondary Outcome Measures
Name Time Method Incidence of bacteremia, urinary infections, infections of the operatory sites, incidence of SDRA, organ dysfunction,mortality, etc. 28 days Incidence of nosocomial pneumopathy Day 8
Trial Locations
- Locations (7)
CH La Roche Sur Yon
🇫🇷La Roche Sur Yon, France
CHU Pontchaillou
🇫🇷Rennes, France
CHU Morvan de Brest
🇫🇷Brest, France
CHU Caen
🇫🇷Caen, France
CHU Bordeaux
🇫🇷Bordeaux, France
CHU Trousseau
🇫🇷Tours, France
Hôtel Dieu
🇫🇷Nantes, France