Difference of plasma carnitine levels after at IV infusion and oral carnitine preparation administration and the stopping dosage

Not Applicable

• Conditions: End stage kidney disease on HD

• Registration Number: JPRN-UMIN000025804
• Lead Sponsor: Hakujikai jin clinic

Brief Summary

Plasma concentrations of TC,FC,and AC at the beginning of the study were not statistically different between different dosing amounts although it was higher in the group administered 900mg/day. TC,FC,AC levels significantly increased after three months upon switching to intravenous administration(TC,FC,AC:p<0.0001),but there was no significant difference in AC/FC during the observation period(p=0.1739). After discontinuation of carnitine administration,TC,FC,and AC levels before the dialysis significantly decreased over three months,and subsequently decreased slowly after the third month(p<0.0001).The average FC value was maintained at normal levels until nine months,but fell below normal values when measured at the 12th month.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-01-23
• Study Completion: 2017-05-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

Not provided

Exclusion Criteria

None

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
plasma concentrations of total carnitine(TC),acyl carnitine(AC),free carnitine(FC),and acyl/free carnitine ratio(AC/FC)