Comparison of Microneedling vs. Autologous Concentrated Growth Factor for the Treatment of Female Androgenetic Alopecia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- TAHC
研究概览
简要总结
Microneedling and autologous concentrated growth factor (CGF) have established their potential effect in inducing hair regrowth. No study has compared the effect of microneedling and CGF in the treatment of female androgenetic alopecia (AGA).
详细描述
Microneedling is a minimally invasive technique consisting of sterile microneedles for repetitive cutaneous puncturing that increase hair regrowth by growth factor release. Concentrated growth factor (CGF) is a form of platelet concentrate (PC) and concentrates higher levels of growth factors because of its varying programmed centrifugation process. Previous studies have showed that CGF injection in hairless scalp could enhance the hair density and optimize the hairless appearance in AGA patients. Both microneedling and CGF have established their potential effect in inducing hair regrowth. No study has compared the effect of microneedling and CGF in the treatment of female androgenetic alopecia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •age between 18 and 65 years;；
- •clinical diagnosis of female pattern hair loss；
- •no previous laser treatments for AGA in the past six months before enrollment； 4) willingness to provide pictures and follow-up studies.
排除标准
- •if presented with severe diseases of internal organs, eyes, or skin;
- •inflammation, infection, or unhealed wounds on the skin around the site of treatment on the head;
- •systematic treatment with corticosteroids or other immunosuppressants and immunomodulators in the past 3 months.
研究组 & 干预措施
microneedling
干预措施: microneedling (Procedure)
autologous concentrated growth factor
干预措施: Autologous Concentrated Growth Factor (Procedure)
5% minoxidil
干预措施: 5% minoxidil (Drug)
结局指标
主要结局
TAHC
时间窗: week 24
Use the trichoscopy to assess the changing number of non-vellus hairs in the target area .
次要结局
- IGA(week 8, week 12, week 16, week 24, week 36)
- Grade of Ludwig and Norwood-Hamilton Classification(week 12, week 24, week 36)
- TAHC(week 8, week 12, week 20, week 36)
- HGQA(week 8, week 12, week 16, week 24, week 36)
- TAHW(week 8, week 12, week 16, week 24, week 36)
- SSA(week 8, week 12, week 16, week 24, week 36)