Preschool Brain Imaging and Behaviour Project (PIP)

Recruiting

• Conditions: autism; autism spectrum disorder (ASD); Attention Deficit Hyperactivity Disorder (ADHD); developmental delay; 10012562

• Registration Number: NL-OMON48368
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 92

Inclusion Criteria

ASD group:
- established or suspected clinical diagnosis of autism spectrum disorder
according to the DSM-5 criteria
- males or females, from age 3 year onward
- non-verbal mental age >= 18 months (Mullen Scales)
- all comorbidities allowed

ADHD group:
- established clinical diagnosis of ADHD according to the DSM-5 criteria
- males or females, from age 4 year onward
- non-verbal mental age >= 18 months (Mullen Scales)
- all comorbidities allowed

DD group:
- clinical evaluation of developmental delay
- males or females, from age 3 year onward
- non-verbal mental age >= 18 months (Mullen Scales)
- all comorbidities allowed

Typically developing controls (TD):
- males and females from the age of 30 months
- no known developmental or medical condition affecting brain development and
behaviour

All groups:
- Availability of a parent or caregiver who has sufficient command of language
to a) provide written confirmed consent, and b) to provide information about
the child*s behaviour, developmental history and symptoms.

Exclusion Criteria

All groups:
- Significant hearing or visual impairments not corrected by glasses or hearing
aids.
- Presence of any MRI contraindications (e.g., metal implants, braces) ,
failure of a parent/ legal caregiver to give informed written consent to MRI
scanning, or to provide contact details for a primary care physician at centres
where this is a precondition for scanning; other reasons why a particular child
may not tolerate the sleep scan (claustrophobia, sensitivity to noise, 'tummy
sleeper')
- MRI counterindications in the parent, or unavailability of any parent, legal
guardian or otherwise familiar and trusted adult person to accompany the child
to the MRI sleep scan.

ASD and ADHD groups:
- The presence of known genetic syndromes that have been associated with ASD,
such as Tubereuze Sclerose, Fragiel X, Rett, Williams, etc.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified