Direct Measurement of Proinsulin Clearance in Humans
- Registration Number
- NCT03998293
- Lead Sponsor
- Mayo Clinic
- Brief Summary
Researchers are trying to determine how quickly proinsulin is cleared from the circulation.
- Detailed Description
proinsulin clearance is necessary to determine the rate of secretion into the circulation
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Weight-stable, non-diabetic subjects from Biobank participants at Mayo Clinic, Rochester
Exclusion Criteria
- Age < 25 or > 65 years (to avoid studying subjects who could have latent type 1 diabetes, or the effects of age extremes in subjects with normal or impaired fasting glucose).
- HbA1c ≥ 6.5%
- Use of glucose-lowering agents.
- For female subjects: positive pregnancy test at the time of enrollment or study
- History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
- Active systemic illness or malignancy.
- Symptomatic macrovascular or microvascular disease.
- Hormone replacement therapy >0.625 mg premarin daily
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description proinsulin clearance Somatostatin all participants will be studied once where somatostatin will be used to block endogenous insulin secretion
- Primary Outcome Measures
Name Time Method Proinsulin Distribution through study completion, each study will take an average of 8 hours The volume of distribution of proinsulin in a given individual
Proinsulin Clearance through study completion, each study will take an average of 8 hours The half-life of proinsulin in a given individual
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mayo Clinic in Rochester
🇺🇸Rochester, Minnesota, United States