euronal olfactory-emotional interaction in depressio

Recruiting

• Conditions: F32.2; F32.1; Severe depressive episode without psychotic symptoms; Moderate depressive episode

• Registration Number: DRKS00016497
• Lead Sponsor: Klinik für Psychotherapie und Psychosomatik, Uniklinikum Carl Gustav Carus Dresden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

For the Patient sample: a diagnosed Major Depression (SCID)

Exclusion Criteria

Exclusion criteria are 1) patients with a history of schizophrenia and/or bipolar disorder 2) history of severe head injury; 3) dependence on alcohol or other substances; 4) concurrent neurological or otorhinolaryngical illness; 5) anosmia; 6) contraindication for MRI.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in olfactory function in the peripheral vs the central dimension (olfactory identification vs olfactory threshold), changes in oddball - reaction times during the three different trials, changes of BOLD Signal according to the different trials (1) visual Stimulation only 2) visual and olfactory Stimulation 3) visual and mechanical trigeminal Stimulation).<br><br>(The exact duration is described in Arm 1 and Arm 2 above).

Secondary Outcome Measures

Name	Time	Method
Evaluation of olfactory function in group comparison (control vs study group), evaluation of changes of BOLD Signal and oddball reaction times according to the different trials in group comparison, relation of anhedonic symptomatology and related questionnaire data to olfactory function and BOLD Signal in group comparison.