Mechanisms for the effect of acetylcysteine on renal function after exposure to radiographic contrast material - Effect of acetylcysteine on renal function after exposure to contrast

Conditions: Radiocontrast-induced nephropathy

Registration Number: EUCTR2006-003509-18-GB

Lead Sponsor: niversity of Edinburgh

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: Male

Target Recruitment: Not specified

Inclusion Criteria

Studies 1 & 3:
Healthy male volunteers aged over 45 years, with a BMI between 22 and 40.

Study 2:
Male volunteers aged over 45 years, with stable CKD stage III and a BMI between 22 and 40, not on metformin.

Study 4:
Male patients aged over 45 years, with stable CKD stage III and a BMI between 22 and 40, not on metformin, undergoing elective coronary angiography.

Study 5:
Male patients aged over 45 years, with stable CKD stage III and a BMI between 22 and 40, not on metformin, undergoing elective CT.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Volunteers for Studies 1, 3
· lack of informed consent
· age <46 years
· current involvement in a clinical trial
· clinically significant co-morbidity: heart failure, hypertension, known
hyperlipidaemia, diabetes mellitus, coagulopathy or bleeding disorder.
· thyroid disease, myasthenia gravis, asthma, atopy, or a history of
allergy/sensitivity to acetylcysteine or contrast medium
· current intake of prescription medicines
· recent infective/inflammatory condition
· blood donation during the preceding three months

Patients for Studies 2, 4 and 5
· lack of informed consent
· age <46 years
· current involvement in a clinical trial
· thyroid disease, myasthenia gravis, asthma, atopy, or a history of
allergy/sensitivity to acetylcysteine or contrast medium
· current intake of metformin
· recent infective/inflammatory condition
· blood donation during the preceding three months