Brain-imaging and Adolescent Neuroscience Consortium

Withdrawn

• Conditions: Alcohol Abuse

• Registration Number: NCT01511679
• Lead Sponsor: Boston Children's Hospital

Brief Summary

This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.

Detailed Description

The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.

Study Timeline

• Study First Submitted: 2012-01-13
• Study First Submitted QC: 2012-01-18
• Study First Posted: 2012-01-19
• Study Start: 2012-09
• Status Verified: 2013-01
• Last Update Submitted: 2013-01-02
• Last Update Posted: 2013-01-03
• Primary Completion: 2017-03
• Study Completion: 2017-09

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• able to read and understand English
• available for follow-up
• parental consent/adolescent assent for those 12-17 years
• consent for those 18-21 years

Exclusion Criteria

• Weight > 300 lbs
• braces or unremovable embedded metal
• claustrophobia or inability to lie still in MRI machine
• current or past 12-mos pregnancy (females)
• requires urgent medical/mental health care

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (4)

Boston University School of Medicine; 🇺🇸 Boston, Massachusetts, United States

Massachusetts Institute of Technology; 🇺🇸 Cambridge, Massachusetts, United States

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States

McLean Hospital; 🇺🇸 Belmont, Massachusetts, United States