NCT02315846已完成不适用
Role of Acetylcholinesterase for the Diagnosis of Postoperative Delirium in Patients Needing Postoperative Monitoring
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- change of acetylcholinesterase (U/l)
研究概览
简要总结
The level of acetylcholinesterase is suspected to correlate with postoperative delirium. The investigators therefore score patients once preoperatively and twice postoperatively with the german version of the delirium-score NuDESC (Nursing Delirium Screening Scale) and compare the results with the acetylcholinesterase activity, butyrylcholinesterase activity and the serum anticholinergic activity (SAA) at corresponding time points.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed written informed consent
- •Elective surgery
排除标准
- •Preexisting psychiatric or neurological disease
- •No surgery
- •Reduced level of consciousness
结局指标
主要结局
change of acetylcholinesterase (U/l)
时间窗: one day before surgery, 1-24h after surgery, 25-72h after surgery
change of acetylcholinesterase in units per litre
次要结局
- change of NuDESC(one day before surgery, 1-24h after surgery, 25-72h after surgery)
- ICD-codes of coexisting diseases(25-72h after surgery)
- change of medication(one day before surgery, 1-24h after surgery, 25-72h after surgery)
- ICD-codes of main disease(25-72h after surgery)
研究者
Christoph Schramm, M.D.
Principal Investigator
Heidelberg University
研究点 (1)
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