Acetylcholinesterase in Postoperative Delirium
- Conditions
- Delirium
- Registration Number
- NCT02315846
- Lead Sponsor
- Heidelberg University
- Brief Summary
The level of acetylcholinesterase is suspected to correlate with postoperative delirium. The investigators therefore score patients once preoperatively and twice postoperatively with the german version of the delirium-score NuDESC (Nursing Delirium Screening Scale) and compare the results with the acetylcholinesterase activity, butyrylcholinesterase activity and the serum anticholinergic activity (SAA) at corresponding time points.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
- Signed written informed consent
- Elective surgery
- Preexisting psychiatric or neurological disease
- No surgery
- Reduced level of consciousness
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change of acetylcholinesterase (U/l) one day before surgery, 1-24h after surgery, 25-72h after surgery change of acetylcholinesterase in units per litre
- Secondary Outcome Measures
Name Time Method change of NuDESC one day before surgery, 1-24h after surgery, 25-72h after surgery change of nursing delirium screening score
ICD-codes of coexisting diseases 25-72h after surgery International classification of diseases-codes of coexisting diseases
change of medication one day before surgery, 1-24h after surgery, 25-72h after surgery change of medication, that could influence a delirium
ICD-codes of main disease 25-72h after surgery International classification of diseases-code of main disease
Trial Locations
- Locations (1)
University of Heidelberg
🇩🇪Heidelberg, Germany