Role of Acetylcholinesterase for the Diagnosis of Postoperative Delirium in Patients Needing Postoperative Monitoring

Heidelberg University1 site in 1 country120 target enrollmentJanuary 2014

ConditionsDelirium

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Delirium
Sponsor: Heidelberg University
Enrollment: 120
Locations: 1
Primary Endpoint: change of acetylcholinesterase (U/l)
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The level of acetylcholinesterase is suspected to correlate with postoperative delirium. The investigators therefore score patients once preoperatively and twice postoperatively with the german version of the delirium-score NuDESC (Nursing Delirium Screening Scale) and compare the results with the acetylcholinesterase activity, butyrylcholinesterase activity and the serum anticholinergic activity (SAA) at corresponding time points.

Registry

clinicaltrials.gov

Start Date

January 2014

End Date

July 2014

Last Updated

7 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Heidelberg University

Responsible Party

Principal Investigator

Christoph Schramm, M.D.

Principal Investigator

Heidelberg University

Eligibility Criteria

Inclusion Criteria

•Signed written informed consent
•Elective surgery

Exclusion Criteria

•Preexisting psychiatric or neurological disease
•No surgery
•Reduced level of consciousness

Outcomes

Primary Outcomes

change of acetylcholinesterase (U/l)

Time Frame: one day before surgery, 1-24h after surgery, 25-72h after surgery

change of acetylcholinesterase in units per litre

Secondary Outcomes

change of NuDESC(one day before surgery, 1-24h after surgery, 25-72h after surgery)
ICD-codes of coexisting diseases(25-72h after surgery)
change of medication(one day before surgery, 1-24h after surgery, 25-72h after surgery)
ICD-codes of main disease(25-72h after surgery)