The acute effect of plant-based meat-alternatives on arterial endothelial function and cardiovascular risk markers

Not Applicable

Recruiting

• Conditions: Cardiovascular risk; Arterial endothelial function; Diet and Nutrition - Other diet and nutrition disorders; Cardiovascular - Normal development and function of the cardiovascular system

• Registration Number: ACTRN12620000011987
• Lead Sponsor: Associate Professor Michael Skilton

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-09
• Last Update Posted: 28 June 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Healthy adults with a BMI less than 30kg/m2, who currently consuming red meat within the NHMRC dietary guidelines

Exclusion Criteria

Current smokers or those who have ceased smoking within the past six months; women who are pregnant or breastfeeding; individuals who have previously been diagnosed with cardiovascular disease, hypertension, pre-diabetes, type 1 diabetes, type 2 diabetes, gastrointestinal disorders or any other major illness; currently using lipid-lowering or vasoactive medications (e.g. anti-hypertensives); those who have any known food intolerances or allergies.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in endothelial function determined by ultrasound scans of Flow-Mediated Dilation (FMD)[Combined 2 and 4 h post consumption]

Secondary Outcome Measures

Name	Time	Method
Change in blood Trimethylamine N-Oxide (TMAO) assessed using blood assay[Baseline and 24 h post consumption];Change in blood triglyceride assessed using blood assay[Baseline, 2, 4 and 24 h post consumption];Change in blood pressure assessed using a commercially available automated oscillometric device[Baseline, 2 and 4 h post consumption]