The effect of vitamin C supplementation on oxidative stress indices and skin repigmentation of patient with vitiligo
Phase 2
Recruiting
- Conditions
- Vitiligo.L80- Diseases of the skin and subcutaneous tissue.
- Registration Number
- IRCT20230123057193N1
- Lead Sponsor
- Research assistant of Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
Definitive diagnosis of vitiligo by a dermatologist, without gender restrictions
Newly diagnosed vitiligo patient (under one month) or less than 10 phototherapy sessions
Adults 20-60 years old
Exclusion Criteria
Being pregnant or breastfeeding
Underlying diseases, including malignancy, history of kidney stones, other chronic and inflammatory diseases except vitiligo
Taking antibiotics, antivirals and antifungals
Use of vitamin C supplements and antioxidants in the last 3 months
Any history of alcohol and tobacco use
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Catalase. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.
- Secondary Outcome Measures
Name Time Method Regimentation. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: vitiligo area scoring index (VASI) score.;Superoxide dismutase. Timepoint: ?????? ?????? (??? ?? ???? ??????) ? 8 ???? ?? ?? ??????. Method of measurement: ELISA assay.;Total oxidant status. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Total antioxidant capacity. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Malondialdehyde. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Glutathione peroxidase. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.