Machine Perfusion in High vs Low/Mid-volume Liver Transplant Centers: a Multicentre Survey

Completed

• Conditions: Organ Preservation Solution
• Interventions: Device: MACHINE PERFUSION

• Registration Number: NCT05662969
• Lead Sponsor: Roberta Angelico

Brief Summary

Introduction: Machine perfusion (MP) was developed to expand the available donor pool and to improve liver transplantation outcomes. Despite optimal results in clinical trials, MP benefit outside of clinical experimentation in unknown. Low/mid volume centres (L/MVCs) may face logistical/economical difficulties that may in turn hamper optimal MP results.

Methods: An Online 22-item survey on the use of machine perfusion for liver transplantation outside of clinical trials, was distributed to worldwide LT centres representatives. Variables of interest included MP logistics, MP technicalities, MP results, post-MP LT results. Responding centres were grouped into high volume centre (HVCs)(defined as \>60 LTs per year in 2019) and L/MVCs. Results from HVCs vs L/MVCs were compared.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-31
• Primary Completion: 2022-01-31
• Study Completion: 2022-03-31
• Study First Submitted: 2022-11-29
• Status Verified: 2022-12
• Study First Submitted QC: 2022-12-20
• Last Update Submitted: 2022-12-20
• Study First Posted: 2022-12-23
• Last Update Posted: 2022-12-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 67

Inclusion Criteria

• LT centres that use MP
• LT centres which perform LT before pandemic time (before 2019 included)
• LT centres which perform LT from cadaveric donors and living donors

Exclusion Criteria

• LT centres that not use MP
• LT centres that use MP but on clinical trials

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Low/mid-volume liver transplant centres	MACHINE PERFUSION	-
High-volume liver transplant centres	MACHINE PERFUSION	-

Primary Outcome Measures

Name	Time	Method
Liver transplant(LT) centres different use of graft after utilization of machine perfusion (MP)	12/2021 - 03/2022	High Volume Centers and Low/Mid Volume centers differ in their rates of graft utilization after Machine perfusion

Secondary Outcome Measures

Name	Time	Method
Liver Transplant outcomes after Machine Perfusion	12/2021 - 03/2022	Reported patient survival rates for Liver Transplant after Machine Perfusion

Trial Locations

Locations (1)

Roberta Angelico; 🇮🇹 Rome, Italy