The level of synovial biomarkers following platelet-rich plasma injection for knee osteoarthritis related to radiographic severity
Completed
- Registration Number
- TCTR20220519005
- Lead Sponsor
- The Biologics for Knee Osteoarthritis Research Unit and The Thailand Science Research and Innovation Fund Chulalongkorn University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 126
Inclusion Criteria
Selection criteria included knee OA according to the American College of Rheumatology (ACR), 45-85 years of age, grade 1 to 4 of radiographic knee OA according to the Kellgren-Lawrence system, body mass index (BMI) < 30, > 90-degree arc of motion, < 10-degree anatomical knee deformity in the coronal plane, and no skin lesion around the affected knee.
Exclusion Criteria
Exclusion criteria included inflammatory arthritis, previous knee surgery, knee pain with an antalgic gait, and thrombocytopenia. In addition, all recruited patients had a 2-week washing-out period for any pain killers or non-steroidal anti-inflammatory drugs (NSAIDs) and joint supplements.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method synovial biomakers at 6 weeks after the intervention level of 12 cytokines from the molecular study
- Secondary Outcome Measures
Name Time Method clinical outcomes within one year after end of the intervention VAS, PROMs (WOMAC and SF-12), and PBMs (TUG, 5*SST, and 3-min WT)