Synovial tissue analysis of factors related to bone-destruction and bone-production in patients with knee arthritis
Recruiting
- Conditions
- joint inflammation1000381610023213
- Registration Number
- NL-OMON40451
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
-Adult (older than 18 years of age)
-Diagnosed with rheumatoid arthritis or peripheral spondyloarthritis according to the treating rheumatologist.
-Undergoing a diagnostic or therapeutic arthroscopy of the knee
-Able to give a written informed consent after reading and understanding the letter of information.
Exclusion Criteria
-Patients who fail to meet the inclusion criteria.
-Patients deemed unfit to participate in the study for whatever reason by the physician performing the study.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Endpoints of the study are analysis of the immune cells in the synovial<br /><br>biopsies of 80 patients with knee arthritis, analysis of molecules involved in<br /><br>osteoblast and osteoclast activation and analysis of the effect of molecules in<br /><br>synovial fluid on activation of osteoclasts and osteoblasts in vitro.</p><br>
- Secondary Outcome Measures
Name Time Method <p>n/a</p><br>