Study of Microbiological Diversity in Exhaled Air in Adult Subjects With Chronic Obstructive Pulmonary Disease (COPD) and Subjects Free of COPD
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 240
- Locations
- 2
- Primary Endpoint
- Number and dominant bacterial species in human exhalations of COPD subjects and non-COPD subjects
Study Overview
Brief Summary
COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations.
a second collection for the year +1 will be made, at the same time (between October and March).
Detailed Description
The subjects will be recruited during a medical visit in the Departments of Pneumology and Occupational and Environmental Pathologies.
After information and inclusion of the subject in the study, a collection of clinical data, the state of health and the smoking status of the subject will be carried out by the clinical study technician.
A collection of the exhalation will also be carried out by the clinical study technician.
Several groups of subjects will be formed according to pathologies (COPD versus non-COPD), age and smoking status
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with chronic obstructive pulmonary disease
- •Age: over 18
- •For non-COPD
- •Absence of chronic obstructive pulmonary disease
- •Age: between 18 and 30 years old and between 45 and 70 years old
Exclusion Criteria
- •Taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants)
- •Person under guardianship or curatorship
- •Pregnant or breastfeeding women
- •Person unable to express his/her opposition, person deprived of liberty
- •Existence of a chronic infectious pulmonary pathology such as (dilation of the bronchi, cystic fibrosis)
Arms & Interventions
Chronic Obstructive Pulmonary Disease (COPD)
Patients with chronic obstructive pulmonary disease will be recruited from the pulmonology or occupational pathology department. They are either active smokers or ex-smokers. They are over 18 years old
Intervention: collection of human exhalation (Other)
NO-Chronic Obstructive Pulmonary Disease
The no-COPD are controls followed in chi créteil for another pathology. They are between 18 and 30 years old and 45 and 70 years old.
They are either:
- Ex-smoker
- Active smoker
- Non-smoker
Intervention: collection of human exhalation (Other)
Outcomes
Primary Outcomes
Number and dominant bacterial species in human exhalations of COPD subjects and non-COPD subjects
Time Frame: Baseline
number and bacterial species
Secondary Outcomes
- Number and dominant bacterial species in human exhalations according to age(Baseline)
- Number and dominant bacterial species in human exhalations for patients returning for consultation 1 year apart during the winter season(1 year)
- Number and dominant bacterial species in human exhalations according to smoking status(Baseline)