Prevalence of HIV-associated neurocognitive disorders (HAND)

Withdrawn

• Conditions: cerebral dysfunction; HIV-associated neurocognitive disorder; 10002252; 10009841

• Registration Number: NL-OMON35948
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 225

Inclusion Criteria

- diagnosis HIV
- 18 years or older
- Capable of speaking and reading Dutch
- Adequate sight and hearing ability to join the study;Inclusion criteria control group Diabetes Mellitus:
- DM type 2
- 18 years or older
- Capable of speaking and reading Dutch
- Adequate sight and hearing ability to join the study
- GFR > 30;Inclusion criteria control group healthy volunteer:
- 18 years or older
- Capable of speaking and reading Dutch
- Adequate sight and hearing ability to join the study

Exclusion Criteria

- Drugs- and/or alcohol abuses (in the past two years)
- Diagnosis of depression (current or last year)
- Current use of anti-depressive or antipsychotic medication
- history of learning disabilities, dyslexia of mental retardation
- History of Cardiac Vascular Attack or neuro-syphilis with sustained brain damage
- Manovascular diseases (cerebral, cardiac and peripheral)
- (Pre)-terminal kidney failure, defined as GFR < 30
- Pregnancy;Exclusion criteria control group diabetes mellitus:
- Drugs- and/or alcohol abuses (in past two years)
- Diagnosis of depression (current or last year)
- Current use of anti-depressive or antipsychotic medication
- history of learning disabilities, dyslexia of mental retardation
- History of Cardiac Vascular Attack or neuro-syphilis with sustained brain damage
- Manovasculaire diseases (cerebral, cardiac and peripheral)
- (Pre)-terminal kidney failure, defined as GFR < 30
- Symptomatic hypoglycaemia in the past 3 days
- Pregnancy;Exclusion criteria control group of healthy volunteers:
- Drugs- and/or alcohol abuses (in past two years)
- Diagnosis of depression (current or last year)
- Current use of anti-depressive or antipsychotic medication
- History of learning disabilities, dyslexia of mental retardation
- History of Cardiac Vascular Attack or neuro-syphilis with sustained brain damage
- Manovasculaire diseases (cerebral, cardiac and peripheral)
- Pregnancy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Is the prevalence of a positive outcome of the HAND screenings test (Hiv<br /><br>Dementia Scale) higher in people living with HIV, compared to people living<br /><br>with diabetes mellitus type 2 or healthy volunteers?</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Can we identify determinants associated with a positive result on the HDS?</p><br>