Behavioral Treatment for Cocaine Dependent Women
- Conditions
- Cocaine Dependence
- Registration Number
- NCT00914381
- Lead Sponsor
- Yale University
- Brief Summary
To compare the efficacy of Community Reinforcement Approach (CRA) and 12-Step Facilitation (TSF) counseling and of voucher based reward therapy (VBRT) and a yoked, non-contingent voucher control (VC) for the treatment of cocaine dependent pregnant women or women with young children.
- Detailed Description
Subjects were randomly assigned to 1 of 4 treatment groups (CRA+VBRT, CRA+VC, TSF+VBRT, TSF+VC). VBRT voucher value increased for each successive cocaine-free urine sample obtained twice weekly during the 1st 12 weeks and was faded from the final earned value to $5 during the last 12 weeks. All subjects earned vouchers for attendance at scheduled twice weekly counseling sessions. Manual-guided CRA and TSF were provided by experienced clinicians.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 145
- Pregnant women meeting DSM IV criteria for cocaine dependence
- Women meeting DSM IV criteria for cocaine dependence with custody of a young child
- Opioid dependence
- Psychosis
- Severe depression
- Current treatment with any anti-depressant or anti-psychotic medication
- Medical instability
- Inability to understand or read English
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Primary Outcome Measures
Name Time Method Cocaine abstinence 24 weeks
- Secondary Outcome Measures
Name Time Method Reduced HIV risk behavior 24 weeks
Trial Locations
- Locations (2)
The APT Foundation, Inc. MRU
🇺🇸New Haven, Connecticut, United States
Yale University School of Medicine
🇺🇸New Haven, Connecticut, United States
The APT Foundation, Inc. MRU🇺🇸New Haven, Connecticut, United States