NCT00846339已完成4 期
[11C] Raclopride PET Imaging Study That Investigates Relation Between Occupancy of Dopamine D2 Receptors and Genotypes of DRD2 After Bupropion Administration
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Dopamine receptor occupancy
研究概览
简要总结
Bupropion has different effects on D2 dopamine receptors according to genotype.
详细描述
Open, one arm, single sequence, 2-period, study stratified into 2 DRD2 genotype groups For subjects who volunteer to cease smoking, genotypes are investigated. Twelve subjects are enrolled (6 - DRD2 Taq1A1 allele, 6 - DRD2 Taq1A2 homozygotes). Subjects receive baseline raclopride PET (High Specific Activity, Low Specific Activity).
- Period 1 Subjects receive 150 mg of bupropion SR every day. After 1 week of medication, pharmacokinetic and PET studies are performed.
- Period 2 Subjects receive 150 mg of bupropion SR twice a day. After 1 week of medication, pharmacokinetic and PET studies are performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Active smoker (more than 10 cigarettes per day for the past 2 years)
排除标准
- •Medical or psychiatric co-morbidity
- •Hypersensitive to bupropion
研究组 & 干预措施
1
Experimental
DRD2 Taq1A1 allele
干预措施: Bupropion (Drug)
2
Experimental
DRD Taq1 A2 homozygote2
干预措施: Bupropion (Drug)
结局指标
主要结局
Dopamine receptor occupancy
时间窗: 1 week
次要结局
- Pharmacokinetic parameters of bupropion and hydroxybupropion(1 week)
研究者
研究点 (1)
Loading locations...
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