terine Cervix repeated Magnetic Resonance Imaging for adaptive treatment planning of cervical cancer radiotherapy. A single-center study

Completed

Conditions: Cervical cancer
10038594

Registration Number: NL-OMON42497

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

* Clinical indication for chemoradiotherapy with curative intent (one of the following):
-FIGO [1] stage IA, IB1 or IIA1 cervical cancer with regional lymph node pathology,
-FIGO stage IA, IB1 or IIA1 cervical cancer with contraindications for surgery
-FIGO stage IB2, IIA2, IIB, IIIA, IIIB, or IVA cervical cancer
* Medical condition that allows chemoradiotherapy with curative intent
* Age * 18 years
* Signed informed consent, obtained before the acquisition of the first additional MRI scan
* Able to comply with the variable bladder filling protocol (drinking and voiding instructions, this protocol is part of standard clinical care)

Exclusion Criteria

* Patients who meet exclusion criteria for MRI at 1.5T following the protocol of the department of Radiology of the UMC Utrecht
* Patients who are mentally or otherwise disabled and/or considered legally incapable
* History of previous pelvic radiotherapy
* Pregnant or breast-feeding patients

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>We will develop a new workflow for MRI-guided adaptive radiotherapy, assessing<br /><br>the accuracy of semi-automatic delineation of target volume and critical<br /><br>organs. Treatment remains according to standard clinical practice, but we will<br /><br>(digitally) simulate our new workflow using the acquired MRI scans. </p><br>

Secondary Outcome Measures