Intraindividual Variability in Sleep and Cognitive Performance in Older Adults
- Conditions
- Insomnia Chronic
- Interventions
- Behavioral: Brief Behavioral Therapy for Insomnia
- Registration Number
- NCT02967185
- Lead Sponsor
- University of Missouri-Columbia
- Brief Summary
The proposed study will examine changes in older insomniacs' cognitive functioning following behavioral treatment for insomnia using a combination of two methods. A traditional repeated measures design will be used to look at group level differences based on performance on a neuropsychological battery administered prior to, immediately after, and 3 months after completing a 4 week behavioral treatment program for insomnia. This data will be analyzed using standard repeated measures analytic techniques. A time-series design will also be used to look at within-subject differences based on a brief cognitive battery that will be self-administered on a daily basis. Data from this daily battery will be examined using intraindividual variability modeling.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 62
- Age >65 years
- Community dwelling
- Available for duration of study
- Insomnia according to American Sleep Disorders Association (1990) criteria: (a) >30 minutes of unwanted awake time, 3 nights per week for at least 6 months and (b) Daytime dysfunction (reported mood, cognitive, social, or occupational impairment)
- Age less than 65
- history of primary sleep disorder (e.g., sleep apnea, narcolepsy)
- history of stroke
- major medical illness known to contribute to sleep problems in last 12 months
- cognitive impairment that interferes with ability to understand treatment (score <23 on Mini-Mental State Examination)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Brief Behavioral Therapy for Insomnia Brief Behavioral Therapy for Insomnia Treatment will consist of 4 weekly, 1 hour sessions and will be conducted by a trained graduate assistant on an individual basis.
- Primary Outcome Measures
Name Time Method Change in diary-assessed total sleep and wake time during sleep from baseline to follow-up from baseline to follow-up, approximately 1 year Participants will complete a daily sleep dairies throughout the study period. They will report their bedtime, waketime, sleep onset latency, and wake time after sleep onset. Total sleep time and total wake time will be calculated from the diaries.
- Secondary Outcome Measures
Name Time Method Change in performance on the Mini-Mental Status Exam from baseline to follow-up, approximately 1 year Mini-Mental Status Exam (MMSE) (Folstein, Folstein, \& McHugh, 1975)
Change in performance on the Trails A & B (Reitan, 1958) from baseline to follow-up, approximately 1 year Trails A \& B (Reitan, 1958) was administered
Change in performance on the Boston Naming Test (BNT) from baseline to follow-up, approximately 1 year Boston Naming Test (BNT)
Change in performance on the Wechsler Memory Scale-3, Logical Memory & Visual Reproduction subtests (WMS-3) Tremblay, 2002) from baseline to follow-up, approximately 1 year Change in performance on the Controlled Oral Word Association from baseline to follow-up, approximately 1 year Controlled Oral Word Association (COWA) (Benton \& Hamsher, 1983)
Change in performance on the California Verbal Learning Test (CVLT, CVLT-II) from baseline to follow-up, approximately 1 year California Verbal Learning Test (CVLT, CVLT-II) (Delis, Kramer, Kaplan, \& Ober, 1987)
Change in actigraphy-assessed sleep variability from baseline to follow-up from baseline to follow-up, approximately 1 year Participants wore an Actiwatch-L (ACTL) (Mini Mitter Co., Inc.) on their non-dominant wrists continuously throughout the study. The sensor of the ACTL is sampled 32 times per second and records peak values for each second. These peak values are then summed into 30-second "activity" counts. These activity counts are downloaded to a personal computer and analyzed using Actiware-Sleep v. 3.3, which uses a validated algorithm to identify periods of as sleep or wake. Total sleep time and total wake time will be computed.
Change in performance on the Rey-Osterreith Complex Figure Test (Rey-O) (Hubley & Tremblay, 2002) from baseline to follow-up, approximately 1 year Change in performance on Wechsler Adult Intelligence Scale-3, Vocabulary & Digit Symbol from baseline to follow-up, approximately 1 year Wechsler Adult Intelligence Scale-3, Vocabulary \& Digit Symbol (subtests) \[WAIS-3\]