MedPath

Food Intake Decisions

Not Applicable
Terminated
Conditions
Healthy
Registration Number
NCT03095833
Lead Sponsor
Hospices Civils de Lyon
Brief Summary

Functional Magnetic resonance study on the effect of cognitive context variables on the perception and valuation of food odorants and flavor. The study is composed of two experiments; in a first experiment we address the question of how valuation of food odors are modulated by 3 cognitive conditions (indulgence, healthy, and neutral). Food odors are delivered using a custom-made olfactometer. Here we hypothesize that cognitive regulation can modulate the primary sensory processing of food odors. We expect that cortical regions related with valuation and cognitive regulation such as the ventromedial prefrontal cortex and the dorsolateral prefrontal cortex operate the modulation of primary olfactory cortex and amygdala. In a second experiment, we aim to reveal the brain areas involved in integrating food color cues with odor and taste stimuli. Here we hypothesize that color cues are capable of biasing flavor attributes of food (flavor intensity), and that this bias occurs at different cortical areas commonly associate with multisensory integration such as the orbitofrontal cortex, insula, amygdala and hippocampus.

Detailed Description

Not available

Recruitment & Eligibility

Status
TERMINATED
Sex
All
Target Recruitment
65
Inclusion Criteria
  • healthy or Prader-Willi
  • right handed
Exclusion Criteria
  • Nursing or pregnant women
  • undergoing medical treatment
  • Having known olfactory disorder
  • neurological or psychiatric history
  • all pertinent conditions according to the use of magnetic resonance imaging.
  • anosmia (partial/total)
  • neurological, psychological or other disease

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
brain activity related to the perception of food odors and flavorHour 1

functional magnetic resonance imaging data

Secondary Outcome Measures
NameTimeMethod
blood alcohol level post experiment10 minutes

reference value for file information

behavioral ratings of odor/flavor valuation by participantsHour 1

behavioral ratings of odor/flavor valuation by participants

Trial Locations

Locations (1)

CH le Vinatier

🇫🇷

Bron, France

CH le Vinatier
🇫🇷Bron, France

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