Rehabilitation after a hip fracture: the effects of dietary protein and exercise on bone and muscle health and quality of life
- Conditions
- Hip fracturebroken hip10017322
- Registration Number
- NL-OMON49870
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 102
* Age >= 65 years
* Acute hip fracture
* Able to give written informed consent
* Mentally competent, as judged by the treating physician
* Admission to a rehabilitation centre that participates in this research
* Allergic, intolerant or hypersensitive to milk/lactose (self-reported)* Not
willing to stop using dietary supplements with the exception of calcium and
vitamin D
* Pathological fracture or periprosthetic fracture
* Abnormal hepatic or renal laboratory parameters, such as estimated glomerular
filtration rate (eGFR) <30 ml/min/1,73 m2 (data from hospital)
* Diagnosis of disorders/diseases where a high protein intake can be harmful,
such as renal impairment or failure, liver disease, or diabetes associated with
nephropathy (elderly care physician has the decisive voice).
* Diagnosis of bone metabolic disorders such as primary hyperparathyroidism,
Paget*s disease, or myeloma
* Taking medication known to strongly alter bone or calcium metabolism, such as
oestrogen, hormone replacement therapy, corticosteroids, anabolic agents,
calcitonin, or bisphosphonates
* Disorders/diseases which may affect ability to follow study protocol and
which cannot be overcome with help of a caregiver
* Current participation in other scientific research
* No permission to request information from the general practitioner/ treating
specialist(s) about medical history, medication use, liver and kidney values,
and details about the broken hip
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Markers of bone turnover: CTX and P1NP<br /><br>* Bone mineral density: total hip, femoral neck, and total body<br /><br>* Insulin-like growth factor 1 and parathyroid hormone levels<br /><br>* Physical performance<br /><br>* Muscle mass</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Quality of life<br />* Inpatient rehabilitation time<br />* Daily life functioning<br />* Fear of falling<br />* Stress<br />* Levels of (free) 25(OH)D, folate, vitamin B12, and vitamin C</p>