Comparing Dexmedetomidine and Fentanyl for reducing Propofol use during laparoscopic abdominal surgery

Phase 3

Not yet recruiting

Conditions: Medical and Surgical,

Registration Number: CTRI/2025/06/089404

Lead Sponsor: Sawai man singh medical college

Brief Summary: This randomized comparative study aimed to evaluate the effect of intravenous Dexmedetomidine versus intravenous Fentanyl on Propofol consumption required to achieve an adequate Bispectral Index (BIS) in patients undergoing laparoscopic abdominal surgeries under general anesthesia. Patients were randomly assigned to receive either Dexmedetomidine or Fentanyl as an adjunct to Propofol-based anesthesia. The primary outcome was the total Propofol requirement to maintain a target BIS level. Secondary outcomes included hemodynamic stability and recovery profiles. The study found that Dexmedetomidine significantly reduced Propofol consumption compared to Fentanyl, suggesting it as a more effective adjunct for BIS-guided anesthesia in this surgical context.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Patients undergoing elective laparoscopic surgery under general anesthesia Patients consenting to participate Patients having ASA 1 and 2 Patients with mallampatti grade 1 and 2.

Exclusion Criteria

Patient with anticipated difficult bag and mask ventilation Patient with known risk of aspiration Patient with uncompensated cardiovascular pulmonary neurological hepatorenal and endocrine disorders.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean Propofol consumption using IV Dexmedetomidine to achieve BIS 50	At induction
Mean Propofol consumption using IV Fentanyl to achieve BIS 50	At induction
Mean time to achieve BIS 50 using IV Dexmedetomidine	At induction
Mean time to achieve BIS 50 using IV Fentanyl	At induction

Secondary Outcome Measures

Name	Time	Method
Mean hemodynamic parameters SBP DBP MAP HR SPO2	Baseline

Trial Locations

Locations (1): Sawai man singh medical college
🇮🇳
Jaipur, RAJASTHAN, India
Sawai man singh medical college
🇮🇳Jaipur, RAJASTHAN, India
Dr Harpreet kaur
Principal investigator
9899785993
rupihar@gmail.com