NCT00650962已完成不适用
Does Longer Pre-shock Cardiopulmonary Resuscitation Improve the Outcome of Patients With Out-of-hospital Cardiac Arrest? A Randomized Control Trial.
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,666
- 试验地点
- 1
- 主要终点
- Sustained ROSC >= 2 hours
研究概览
简要总结
- Pre-shock cardiopulmonary resuscitation might benefit the survival of out-of-hospital cardiac patients with ventricular fibrillation / ventricular tachycardia in a post-hoc analysis of a prehospital trial conducted in Europe (L.Wik,2002). However, it's effectiveness in the Asian countries, where most firstly recorded rhythm in out-of-hospital cardiac arrests patients were asystole/pulseless electric activity rather than ventricular fibrillation / ventricular tachycardia, were not explored yet.
- This trial was designed to exam if pre-shock cardiopulmonary resuscitation by emergency medical technicians improves the outcome of all out-of-hospital cardiac arrest patients in an Asian metropolitan city.
详细描述
- Different from data from the Western countries, non-shockable rhythm (Asystole/pulseless electric activity) was responsible for most out-of-hospital cardiac arrest patients(80%~90%) in metropolitan Taipei.
- Response time in Taipei emergency medical service was longer than 5 minutes.
- Bystander cardiopulmonary resuscitation rate were relatively low in Taipei.
- Cardiopulmonary resuscitation is the only known method to save out-of-hospital cardiac arrest patients with asystole/pulseless electric activity. For those suffered from ventricular fibrillation/ ventricular tachycardia,previous studies revealed pre-shock cardiopulmonary resuscitation may have the potential to improve the outcome.
- Study hypothesis: Compared with current standard resuscitative sequence (basic life support protocol in Guideline 2005), longer pre-shock cardiopulmonary resuscitation provided to all out-of-hospital cardiac arrest patients in Taipei may improve the outcome of them.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with out-of-hospital cardiac arrest
排除标准
- •Age < 18y/o
- •Airway obstruction
- •Submersion
- •Sign of obvious death
- •existing do not resuscitate (DNAR) order
- •family refusal
- •preceding CPR by BLS teams for longer than 2 minutes.
研究组 & 干预措施
CPR first
Active Comparator
Compression First (CF)
干预措施: cardiopulmonary resuscitation (Other)
Analysis First
Active Comparator
Rhythm analysis first
干预措施: Rhythm analysis (Other)
结局指标
主要结局
Sustained ROSC >= 2 hours
时间窗: 180 days
次要结局
- survival to hospital discharge(180 days)
- surival to ICU admission(180 days)
- Rates of good neurology recovery (CPC 1 &2)(180 days)
研究者
研究点 (1)
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