Pre-shock Cardiopulmonary Resuscitation to Patients With Out-of-hospital Resuscitation, A Randomised Clinical Trial

Not Applicable

Completed

• Conditions: Cardiac Arrest
• Interventions: Other: Rhythm analysis; Other: cardiopulmonary resuscitation

• Registration Number: NCT00650962
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

1. Pre-shock cardiopulmonary resuscitation might benefit the survival of out-of-hospital cardiac patients with ventricular fibrillation / ventricular tachycardia in a post-hoc analysis of a prehospital trial conducted in Europe (L.Wik,2002). However, it's effectiveness in the Asian countries, where most firstly recorded rhythm in out-of-hospital cardiac arrests patients were asystole/pulseless electric activity rather than ventricular fibrillation / ventricular tachycardia, were not explored yet.

2. This trial was designed to exam if pre-shock cardiopulmonary resuscitation by emergency medical technicians improves the outcome of all out-of-hospital cardiac arrest patients in an Asian metropolitan city.

Detailed Description

1. Different from data from the Western countries, non-shockable rhythm (Asystole/pulseless electric activity) was responsible for most out-of-hospital cardiac arrest patients(80%\~90%) in metropolitan Taipei.

2. Response time in Taipei emergency medical service was longer than 5 minutes.

3. Bystander cardiopulmonary resuscitation rate were relatively low in Taipei.

4. Cardiopulmonary resuscitation is the only known method to save out-of-hospital cardiac arrest patients with asystole/pulseless electric activity. For those suffered from ventricular fibrillation/ ventricular tachycardia,previous studies revealed pre-shock cardiopulmonary resuscitation may have the potential to improve the outcome.

5. Study hypothesis: Compared with current standard resuscitative sequence (basic life support protocol in Guideline 2005), longer pre-shock cardiopulmonary resuscitation provided to all out-of-hospital cardiac arrest patients in Taipei may improve the outcome of them.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2008-02
• Study First Submitted: 2008-03-30
• Study First Submitted QC: 2008-04-01
• Study First Posted: 2008-04-02
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Status Verified: 2011-12
• Last Update Submitted: 2012-01-02
• Last Update Posted: 2012-01-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1666

Inclusion Criteria

• Patients with out-of-hospital cardiac arrest

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Exclusion Criteria

• Trauma
• Age < 18y/o
• Airway obstruction
• Submersion
• Sign of obvious death
• existing do not resuscitate (DNAR) order
• family refusal
• preceding CPR by BLS teams for longer than 2 minutes.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Analysis First	Rhythm analysis	Rhythm analysis first
CPR first	cardiopulmonary resuscitation	Compression First (CF)

Primary Outcome Measures

Name	Time	Method
Sustained ROSC >= 2 hours	180 days

Secondary Outcome Measures

Name	Time	Method
survival to hospital discharge	180 days
surival to ICU admission	180 days
Rates of good neurology recovery (CPC 1 &2)	180 days

Trial Locations

Locations (1)

Department of Emergency Medicine, National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan