Modulating Amygdala and dACC activity during reward volatility in affective decision-making

Conditions: fundamenteel neurowetenschappelijk onderzoek in gezonde volwassenen
normal brain function

Registration Number: NL-OMON56892

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 64

Inclusion Criteria

- Between 18-40 years of age;
- The ability and agreement to provide informed consent in sound body and mind,
and the ability to fulfil the study*s requirements

Exclusion Criteria

- Under 18 years of age;
- The consumption of more than four alcoholic units or any recreational
psychoactive drugs within 24 hours before participation;
- A history of serious head trauma or brain surgery, or (close relatives with)
epilepsy, convulsion, or seizure;
- Any current episodes of psychiatric or neurological disorders;
- Claustrophobia;
- Current pregnancy;
- Predisposition for fainting spells (syncope);
- Hearing problems or ringing in the ears;
- Implanted metal devices or large ferromagnetic fragments in the head or upper
body (excluding dental wire), or jewellery/piercing that cannot be removed;
- Use of a medical plaster that cannot or may not be taken off (e.g., nicotine
plaster);
- Use of (prescription) medication interacting with neuromodulation;
- Skin disease or sensitivity at intended stimulation sites;
- Calcifications in the brain in the acoustic path, see Chapter 6.4 of the C1
for a more elaborate explanation.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>During the task, participants' responses will control a joystick whose<br /><br>movements will be recorded. These behavioural responses will be categorised<br /><br>based on in-session conditions and between-session stimulation conditions. This<br /><br>allows us to compare the difference in behavioural responses between each<br /><br>condition.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Cortical changes in oxygen usage will be mapped using fMRI during task<br /><br>performance. With this, we can map oxygen usage in brain areas including the<br /><br>ones that were shown to be involved by previous studies such as the Amygdala,<br /><br>dACC. This activity can then be related to between-session stimulation<br /><br>conditions and within-session task conditions.<br /><br><br /><br>In addition to this, we will also use measures of autonomic arousal during the<br /><br>sessions such as respiratory activity, heart rate and electrodermal activity.</p><br>