Effect of Statins on epigenetic reprogramming of monocytes in patients with elevated levels of LDL: an observational study
Recruiting
- Conditions
- dyslipidemiahigh cholesterolhypercholsterolemia10013317
- Registration Number
- NL-OMON42146
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 45
Inclusion Criteria
Elevated levels of LDL in the blood (LDL >4.9 mmol/l)
Age > 18 years
Exclusion Criteria
- Current lipid lowering treatment
- Previous cardiovascular events
- Known malignant disorders or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator.
- Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.
- Clinical signs of acute infection
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Epigenetic changes in the promotor regions of pro-inflammatory cytokines in<br /><br>monocytes before and after statin treatment</p><br>
- Secondary Outcome Measures
Name Time Method <p>cytokine release upon stimulation with TLR agonists and ex vivo<br /><br>characterization of monocytes</p><br>