Modulation of placental angiogenesis by active cholesterol transport in intrauterine growth restriction.

Recruiting

• Conditions: O36.5; O14.1; O24.4; Maternal care for poor fetal growth; Severe pre-eclampsia; Diabetes mellitus arising in pregnancy

• Registration Number: DRKS00009897
• Lead Sponsor: niversitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Gynäkologie und Geburtshilfe

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 540

Inclusion Criteria

Case group: pregnant women with suspected IUGR with / without preeclampsia or diabetes.
control group: pregnant women in which IUGR has been excluded with / without preeclampsia or diabetes.

Exclusion Criteria

fetal anomalies, abnormal fetal karyotype, patients with clinical or biochemical signs of infection, positive TORCH screening results, or other severe maternal metabolic disorders, and the patient's withdrawal from the study.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Study aim: In the study we test the hypothesis that cholesterol-transport processes are involved in the regulation of placental and fetal angiogenesis in IUGR.

Secondary Outcome Measures

Name	Time	Method
Secondary study aim: In the study we test the hypothesis that a disturbed cholesterol transport is involved in the development cardiovascular diseases later in life.